Update in Hormone Therapy Use in Menopause

被引：87

作者：

Taylor, Hugh S. ^{[2
]}

Manson, JoAnn E. ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Brigham & Womens Hosp, Div Prevent Med, Boston, MA 02215 USA

[2] Yale Univ, Sch Med, Div Reprod Endocrinol & Infertil, New Haven, CT 06520 USA

来源：

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | 2011年 / 96卷 / 02期

关键词：

ESTROGEN PLUS PROGESTIN; CONJUGATED EQUINE ESTROGENS; BREAST-CANCER RISK; RANDOMIZED-CONTROLLED-TRIAL; POSTMENOPAUSAL WOMEN; BAZEDOXIFENE/CONJUGATED ESTROGENS; REPLACEMENT THERAPY; CLINICAL-TRIAL; OSTEOPOROSIS PREVENTION; COLORECTAL-CANCER;

D O I：

10.1210/jc.2010-0536

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The original report from the Women's Health Initiative (WHI) changed our understanding of the benefits and risks of hormone therapy. Since that time, reanalysis of the WHI and additional data from other studies have further refined these concepts. Here we provide an update on recent advances in the field. Menopausal hormone therapy continues to have a clinical role in the management of vasomotor symptoms. However, our understanding of the role of hormones in cardiovascular disease and breast cancer continues to evolve. Further analyses of the effect of age and proximity to menopause at the time of initiation of therapy, duration of treatment, dose, route of administration, and the persistence of risks and benefits after stopping hormone therapy are described. In addition, recent data have emerged suggesting that there may be a link between hormone therapy and cancers of the lung and ovary. Finally, we discuss new advances in hormone therapy that will likely lead to a more favorable benefit-to-risk ratio, enabling safer effective menopausal symptom relief. (J Clin Endocrinol Metab 96: 255-264, 2011)

引用

页码：255 / 264

页数：10

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