KIRs and their HLA ligands in Remitting-Relapsing Multiple Sclerosis

被引：37

作者：

Fusco, Caterina ^{[1
]}

Guerini, Franca Rosa ^{[2
]}

Nocera, Giustina ^{[3
]}

Ventrella, Gianluca ^{[4
]}

Caputo, Domenico ^{[5
]}

Valentino, Maria Antonietta ^{[1
]}

Agliardi, Cristina ^{[2
]}

Gallotti, Jacopo ^{[3
]}

Morra, Vincenzo Brescia ^{[4
]}

Florio, Ciro ^{[6
]}

Clerici, Mario ^{[2
,7
]}

Lombardi, Maria Luisa ^{[3
]}

机构：

[1] AORN A Cardarelli, Immunoematol & Trasfus Serv, I-80131 Naples, Italy

[2] Don C Gnocchi Fdn IRCCS, Lab Mol Med & Biotechnol, Milan, Italy

[3] Natl Canc Inst, Dept Expt Oncol, Naples, Italy

[4] Univ Naples Federico 2, Dept Neurol Sci, Naples, Italy

[5] Fdn Don C Gnocchi, IRCCS, Multiple Sclerosis Unit, Milan, Italy

[6] AORN A Cardarelli, Dept Neurosci, I-80131 Naples, Italy

[7] Univ Milan, Dept Biomed Sci & Technol, I-20122 Milan, Italy

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2010年 / 229卷 / 1-2期

关键词：

Multiple sclerosis; KIRs; HLA-KIR ligands; NATURAL-KILLER-CELLS; IMMUNOGLOBULIN-LIKE RECEPTOR; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; T-CELLS; CLASS-I; REGULATORY ROLE; NK CELLS; DISEASE; GENES; SUSCEPTIBILITY;

D O I：

10.1016/j.jneuroim.2010.08.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Killer Immunoglobulin-like Receptor (KIR) genes may affect both resistance and susceptibility to autoimmune disorders, but their role in the pathogenesis of Multiple Sclerosis (MS) is still unclear. To evaluate the involvement of KIRs and their HLA ligands in the development of MS we performed genotyping of HLA -A, -B, -Cw, -DRB1 and KIRs loci in 121 RRMS patients and 103 healthy controls (HC). Results evidenced a possible protective role of the activating KIR2DS1 gene (p(y) = 0.001; OR:0.38), enhanced in the presence of its ligand group HLA-C2 (p(y) = 0.0001; OR:0.23). Our data suggest that the presence of functional compounds of activating KIR receptors together with their HLA ligands, allowing the immunomodulatory function of NK cells, may have a protective role against the disease. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：232 / 237

页数：6

共 41 条

[1] Immunoregulatory factors in multiple sclerosis patients during and after pregnancy: relevance of natural killer cells [J].

Airas, L. ;

Saraste, M. ;

Rinta, S. ;

Elovaara, I. ;

Huang, Y. -H. ;

Wiendl, H. .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2008, 151 (02) :235-243

[2] HLA Class I Subtype-Dependent Expansion of KIR3DS1+ and KIR3DL1+ NK Cells during Acute Human Immunodeficiency Virus Type 1 Infection [J].

Alter, Galit ;

Rihn, Suzannah ;

Walter, Katharine ;

Nolting, Anne ;

Martin, Maureen ;

Rosenberg, Eric S. ;

Miller, Jeffrey S. ;

Carrington, Mary ;

Altfeld, Marcus .

JOURNAL OF VIROLOGY, 2009, 83 (13) :6798-6805

[3] A population-based cohort study of KIR genes and genotypes in relation to cervical intraepithelial neoplasia [J].

Arnheim, L ;

Dillner, J ;

Sanjeevi, CB .

TISSUE ANTIGENS, 2005, 65 (03) :252-259

[4] HLA-DR2 dose effect on susceptibility to multiple sclerosis and influence on disease course [J].

Barcellos, LF ;

Oksenberg, JR ;

Begovich, AB ;

Martin, ER ;

Schmidt, S ;

Vittinghoff, E ;

Goodin, DS ;

Pelletier, D ;

Lincoln, RR ;

Bucher, P ;

Swerdlin, A ;

Perick-Vance, MA ;

Haines, JL ;

Hauser, SL .

AMERICAN JOURNAL OF HUMAN GENETICS, 2003, 72 (03) :710-716

[5] The killer immunoglobulin-like receptor gene cluster: Tuning the genome for defense [J].

Bashirova, Arman A. ;

Martin, Maureen P. ;

McVicar, Daniel W. ;

Carrington, Mary .

ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS, 2006, 7 :277-300

[6] HLA-class I markers and multiple sclerosis susceptibility in the Italian population [J].

Bergamaschi, L. ;

Leone, M. A. ;

Fasano, M. E. ;

Guerini, F. R. ;

Ferrante, D. ;

Bolognesi, E. ;

Barizzone, N. ;

Corrado, L. ;

Naldi, P. ;

Agliardi, C. ;

Dametto, E. ;

Salvetti, M. ;

Visconti, A. ;

Galimberti, D. ;

Scarpini, E. ;

Vercellino, M. ;

Bergamaschi, R. ;

Monaco, F. ;

Caputo, D. ;

Momigliano-Richiardi, P. ;

D'Alfonso, S. .

GENES AND IMMUNITY, 2010, 11 (02) :173-180

[7] Distribution of killer cell immunoglobulin-like receptors genes in the Italian Caucasian population [J].

Bontadini, A. ;

Testi, M. ;

Cuccia, M. C. ;

Martinetti, M. ;

Carcassi, C. ;

Chiesa, A. ;

Cosentini, E. ;

Dametto, E. ;

Frison, S. ;

Iannone, A. M. ;

Lombardo, C. ;

Malagoli, A. ;

Mariani, M. ;

Mariotti, L. ;

Mascaretti, L. ;

Mele, L. ;

Miotti, V. ;

Nesci, S. ;

Ozzella, G. ;

Piancatelli, D. ;

Romeo, G. ;

Tagliaferri, C. ;

Vatta, S. ;

Andreani, M. ;

Conte, R. .

JOURNAL OF TRANSLATIONAL MEDICINE, 2006, 4 (1)

[8] Natural killer cells, killer immunoglobulin-like receptors and human leucocyte antigen class I in disease [J].

Boyton, R. J. ;

Altmann, D. M. .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2007, 149 (01) :1-8

[9] HLA-A Confers an HLA-DRB1 Independent Influence on the Risk of Multiple Sclerosis [J].

Brynedal, Boel ;

Duvefelt, Kristina ;

Jonasdottir, Gudrun ;

Roos, Izaura M. ;

Akesson, Eva ;

Palmgren, Juni ;

Hillert, Jan .

PLOS ONE, 2007, 2 (07)

[10] Hierarchy of resistance to cervical neoplasia mediated by combinations of killer immunoglobulin-like receptor and human leukocyte antigen loci [J].

Carrington, M ;

Wang, S ;

Martin, MP ;

Gao, XJ ;

Schiffman, M ;

Cheng, J ;

Herrero, R ;

Rodriguez, AC ;

Kurman, R ;

Mortel, R ;

Schwartz, P ;

Glass, A ;

Hildesheim, A .

JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 201 (07) :1069-1075

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