Cannabinoid receptor 2 selective agonists and Alzheimer's disease: An insight into the therapeutic potentials

被引：16

作者：

Magham, Sai Varshini ^{[1
]}

Thaggikuppe Krishnamurthy, Praveen ^{[1
]}

Shaji, Neenu ^{[1
]}

Mani, Lalithkumar ^{[1
]}

Balasubramanian, Shivaramakrishnan ^{[1
]}

机构：

[1] JSS Acad Higher Educ & Res, Dept Pharmacol, JSS Coll Pharm, Ooty, India

来源：

JOURNAL OF NEUROSCIENCE RESEARCH | 2021年 / 99卷 / 11期

关键词：

CB1; CNS; endocannabinoid system (ECS); neuroprotection; TRANSGENIC MOUSE MODEL; CENTRAL-NERVOUS-SYSTEM; ACID AMIDE HYDROLASE; CB2; RECEPTOR; AMYLOID-BETA; IN-VITRO; ENDOCANNABINOID SYSTEM; FUNCTIONAL SELECTIVITY; SIGNAL-TRANSDUCTION; ACTIVATION;

D O I：

10.1002/jnr.24933

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Endocannabinoid system has been extensively studied in recent decades, particularly the cannabinoid receptors CB1 and CB2, due to their important role in neuroinflammation. Among these, CB2 has gained prominence due to its selective overexpression in glial cells during neuroinflammation. In contrast to CB1 agonists, CB2 agonists have no side effects such as ataxia, hypothermia, euphoria, psychological, or addiction liabilities. CB2 and its selective agonists' above-mentioned unique properties have become a research focus in neurodegenerative disorders such as Alzheimer's disease (AD). The review discusses the neuroprotective role of CB receptors, particularly CB2, in AD, as well as the significance and limitations of this research.

引用

页码：2888 / 2905

页数：18

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