5-Fluorouracil encapsulated magnetic nanohydrogels for drug-delivery applications

被引：27

作者：

Jayaramudu, Tippabattini ^{[1
,2
,3
]}

Raghavendra, Gownolla Malegowd ^{[2
,4
]}

Varaprasad, Kokkarachedu ^{[5
]}

Raju, Konduru Mohana ^{[2
]}

Sadiku, Emmanuel Rotimi ^{[3
]}

Kim, Jaehwan ^{[1
]}

机构：

[1] Inha Univ, Dept Mech Engn, Ctr Nano Cellulose Future Composites, 253 Yonghyun Dong, Inchon 402751, South Korea

[2] Sri Krishnadevaraya Univ, Dept Polymer Sci & Technol, Synthet Polymer Lab, Anantapur 515003, Andhra Pradesh, India

[3] Tshwane Univ Technol, Dept Polymer Technol, Council Sci & Ind Res Campus, Pretoria, South Africa

[4] Yonsei Univ, Dept Packaging, 1 Yonseidae Gil, Wonju 220710, Gangwon Do, South Korea

[5] CIPA, Ave Collao 1202,Edificio Lab CIPA, Concepcion, Chile

来源：

JOURNAL OF APPLIED POLYMER SCIENCE | 2016年 / 133卷 / 37期

基金：

新加坡国家研究基金会;

关键词：

biocompatibility; biomedical applications; drug-delivery systems; gels; hydrophilic polymers; GREEN TEA EXTRACT; HYDROGEL NANOCOMPOSITES; CHITOSAN HYDROGELS; IRON NANOPARTICLES; RELEASE; CANCER; FE3O4; BIOCOMPATIBILITY; INACTIVATION; DEGRADATION;

D O I：

10.1002/app.43921

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

For the first time, green-tea (GT)-based magnetic nanohydrogels were developed for drug-delivery purposes. The hydrogel matrices were fabricated via the in situ polymerization of acrylamide with GT molecules. Magnetic nanoparticles were synthesized by the reduction of the 1:2 molar ratio mixture of ferrous sulfate heptahydrate and ferric chloride hexahydrate with an ammonia solution. A chemotherapeutic drug, 5-fluorouracil, was chosen as a model drug, and its releasing profiles in the presence and absence of the external magnetic field were evaluated at a pH of 7.4. We observed that in the presence of the applied magnetic field, these magnetic nanohydrogels released 2.86% more drug than in the absence of a magnetic field. The magnetic nanohydrogels were characterized by X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, vibrating sample magnetometry, and transmission electron microscopy. (c) 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 43921.

引用

页数：10

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