Genetic analysis of HLA-DRA region variation in Taiwanese Parkinson's disease

被引：15
作者：
Chiang, Han-Lin [1 ]
Lee-Chen, Guey-Jen [2 ]
Chen, Chiung Mei [3 ]
Chen, Yi-Chun [3 ]
Lee, Chei-Mei [2 ]
Liao, Ming-Hui [3 ]
Wu, Yih-Ru [3 ]
机构：
[1] Buddhist Tzu Chi Gen Hosp, Dept Neurol, Taipei Branch, Taipei, Taiwan
[2] Natl Taiwan Normal Univ, Dept Life Sci, Taipei, Taiwan
[3] Chang Gung Univ, Coll Med, Chang Gung Mem Hosp, Dept Neurol, Linkou, Taiwan
来源：
PARKINSONISM & RELATED DISORDERS | 2012年 / 18卷 / 04期
关键词：
HLA; Parkinson's disease; Polymorphism; Disease association; GENOME-WIDE ASSOCIATION; MULTIPLE-SCLEROSIS; RISK-FACTORS; SUSCEPTIBILITY; HAPLOTYPES; VARIANTS; JAPANESE; LOCI; SNCA;
D O I：
10.1016/j.parkreldis.2011.12.014
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Parkinson's disease (PD) is a neurodegenerative disorder comprising both motor and cognitive disability. The pathogenesis of the disease is still unclear; however, neuroinflammation seemed to play a role. A recent genome-wide association study (GWAS) reported an association between HLA-DRA rs3129882 and the development of PD in Caucasian populations. In this study, we observe no association between this single nucleotide polymorphism and PD in a Taiwanese population. The possible reasons include different ethnicity with genomic differences and environmental factors in different geographical regions. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：391 / 393
页数：3
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