Genetic analysis of HLA-DRA region variation in Taiwanese Parkinson's disease

被引：15

作者：

Chiang, Han-Lin ^{[1
]}

Lee-Chen, Guey-Jen ^{[2
]}

Chen, Chiung Mei ^{[3
]}

Chen, Yi-Chun ^{[3
]}

Lee, Chei-Mei ^{[2
]}

Liao, Ming-Hui ^{[3
]}

Wu, Yih-Ru ^{[3
]}

机构：

[1] Buddhist Tzu Chi Gen Hosp, Dept Neurol, Taipei Branch, Taipei, Taiwan

[2] Natl Taiwan Normal Univ, Dept Life Sci, Taipei, Taiwan

[3] Chang Gung Univ, Coll Med, Chang Gung Mem Hosp, Dept Neurol, Linkou, Taiwan

来源：

PARKINSONISM & RELATED DISORDERS | 2012年 / 18卷 / 04期

关键词：

HLA; Parkinson's disease; Polymorphism; Disease association; GENOME-WIDE ASSOCIATION; MULTIPLE-SCLEROSIS; RISK-FACTORS; SUSCEPTIBILITY; HAPLOTYPES; VARIANTS; JAPANESE; LOCI; SNCA;

D O I：

10.1016/j.parkreldis.2011.12.014

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Parkinson's disease (PD) is a neurodegenerative disorder comprising both motor and cognitive disability. The pathogenesis of the disease is still unclear; however, neuroinflammation seemed to play a role. A recent genome-wide association study (GWAS) reported an association between HLA-DRA rs3129882 and the development of PD in Caucasian populations. In this study, we observe no association between this single nucleotide polymorphism and PD in a Taiwanese population. The possible reasons include different ethnicity with genomic differences and environmental factors in different geographical regions. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：391 / 393

页数：3

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