Cross Coupling of Acyl and Aminyl Radicals: Direct Synthesis of Amides Catalyzed by Bu4NI with TBHP as an Oxidant

被引：390

作者：

Liu, Zhaojun ^{[1
]}

Zhang, Jie ^{[1
]}

Chen, Shulin ^{[1
]}

Shi, Erbo ^{[1
]}

Xu, Yuan ^{[1
]}

Wan, Xiaobing ^{[1
,2
]}

机构：

[1] Soochow Univ, Coll Chem Chem Engn & Mat Sci, Key Lab Organ Synth Jiangsu Prov, Suzhou 215123, Peoples R China

[2] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 13期

关键词：

aldehydes; amides; cross-coupling; formamides; radical reactions; TERT-BUTYL HYDROPEROXIDE; MONOXIDE-FREE AMINOCARBONYLATION; C-H ACTIVATION; CARBOXYLIC-ACIDS; ARYL HALIDES; ONE-POT; INTERMOLECULAR HYDROACYLATION; CARBON-MONOXIDE; METAL-FREE; TRANSFER HYDROAMINATION;

D O I：

10.1002/anie.201108763

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A radical solution: A Bu 4NI/tert-butyl hydroperoxide (TBHP) catalyzed synthesis of amides through a cross-coupling reaction between acyl and aminyl radicals is described. This method involves the combination of aldehyde C-H bond functionalization and decarbonylation of N,N-disubstituted formamides (see scheme). The cross-coupling is metal-free, has a wide substrate scope, operational simplicity, and gives high yields on scale-up. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：3231 / 3235

页数：5

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