Oxidative stress, cytoxicity, and cell mortality induced by nano-sized lead in aqueous suspensions

被引：35

作者：

Cornejo-Garrido, Hilda ^{[1
,2
]}

Kibanova, Daria ^{[1
]}

Nieto-Camacho, Antonio ^{[3
]}

Guzman, Jose ^{[4
]}

Ramirez-Apan, Teresa ^{[3
]}

Fernandez-Lomelin, Pilar ^{[5
]}

Laura Garduno, Maria ^{[1
]}

Cervini-Silva, Javiera ^{[1
,6
,7
]}

机构：

[1] Univ Autonoma Metropolitana Cuajimalpa, Dept Proc & Tecnol, Mexico City, DF, Mexico

[2] Univ Nacl Autonoma Mexico, Posgrado Ciencias Tierra, Mexico City 04510, DF, Mexico

[3] Univ Nacl Autonoma Mexico, Lab Ciencias Biolog, Inst Quim, Mexico City 04510, DF, Mexico

[4] Cent Invest Ciencia Aplicada & Tecnol Avanzada, Unidad Legaria, Mexico City, DF, Mexico

[5] Univ Nacl Autonoma Mexico, Inst Geog, Mexico City 04510, DF, Mexico

[6] NASA, Astrobiol Inst, Washington, DC USA

[7] Lawrence Berkeley Natl Lab, Div Earth Sci, Berkeley, CA USA

来源：

CHEMOSPHERE | 2011年 / 84卷 / 10期

关键词：

Water-stable; Stable nanoparticles; Lipid peroxidation; Lead nanoparticles; Biological activity; LIPID-PEROXIDATION; HYDROXAMATE SIDEROPHORES; NITRIC-OXIDE; IRON; RAT; DISSOLUTION; ADSORPTION; PB(II); GROWTH; CRYSTALLIZATION;

D O I：

10.1016/j.chemosphere.2011.05.018

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

This paper reports on the effect of aqueous and nano-particulated Pb on oxidative stress (lipid peroxidation), cytoxicity, and cell mortality. As determined by the Thiobarbituric Acid Reactive Substances (TBARS) method, only 6 h after incubation aqueous suspensions bearing nano-sized PbO2, soluble Pb(II), and brain-homogenate only suspensions, were determined to contain as much as ca. 7, 5, and 1 nmol TBARS mg protein(-1), respectively. Exposure of human cells (central nervous system, prostate, leukemia, colon, breast, lung cells) to nano-PbO2 led to cell-growth inhibition values (%) Ca. <= 18.7%. Finally, as estimated by the Artemia sauna test, cell mortality values were found to show high-survival larvae rates. Microscopic observations revealed that Pb particles were swallowed, but caused no mortality, however. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：1329 / 1335

页数：7

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