Synthesis and Biological Evaluation of Some New 2,4,6-Trisubstituted Pyrimidines

被引：0
|
作者：
Sridhar, S. [1 ]
Prasad, Y. Rajendra [2 ]
Dinda, S. C. [3 ]
机构：
[1] Malla Reddy Coll Pharm, Secunderabad 500014, India
[2] Andhra Univ, Univ Coll Pharmaceut Sci, Vishakapatanam 530003, Andhra Pradesh, India
[3] Berhampur Univ, Sch Pharmaceut Educ & Res, Berhampur 760007, Orissa, India
来源：
ASIAN JOURNAL OF CHEMISTRY | 2012年 / 24卷 / 03期
关键词：
Pyrimidines; Synthesis; Antimicrobial activity;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In the present study, 3-acetyl-2,5-dimethylfuran on condensation with various aromatic and heterocyclic aldehydes in ethanolic KOH solution yielded the corresponding chalcones (3a-n). These chalcones were reacted with guanidine hydrochloride in presence of potassium hydroxide and ethanol to give pyrimidines (4a-n). All these compounds were characterized by IR, H-1 NMR spectroscopic data and microanalyses. When these compounds were evaluated for anti-inflammatory and antimicrobial activities, some of them were found to possess significant activity, when compared to standard drugs.
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页码：1130 / 1134
页数：5
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