Cell-SELEX: Novel perspectives of aptamer-based therapeutics

被引：121
|
作者：
Guo, Ke-Tai [1 ]
Paul, Angela [1 ]
Schichor, Christian [2 ]
Ziemer, Gerhard [1 ]
Wendel, Hans P. [1 ]
机构：
[1] Univ Tubingen Hosp, Dept Thorac Cardiac & Vasc Surg, D-72076 Tubingen, Germany
[2] Univ Munich, Klinikum Grosshadern, Dept Neurosurg, D-81377 Munich, Germany
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2008年 / 9卷 / 04期
关键词：
cell-SELEX; aptamer; nanotechnology;
D O I：
10.3390/ijms9040668
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Aptamers, single stranded DNA or RNA molecules, generated by a method called SELEX (systematic evolution of ligands by exponential enrichment) have been widely used in various biomedical applications. The newly developed Cell-SELEX (cell based-SELEX) targeting whole living cells has raised great expectations for cancer biology, -therapy and regenerative medicine. Combining nanobiotechnology with aptamers, this technology opens the way to more sophisticated applications in molecular diagnosis. This paper gives a review of recent developments in SELEX technologies and new applications of aptamers.
引用
收藏
页码：668 / 678
页数：11
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