Role of mitophagy in the neurodegenerative diseases and its pharmacological advances: A review

被引：16

作者：

Wang, Qixia ^{[1
]}

Xue, Haoyuan ^{[1
]}

Yue, Yundi ^{[1
]}

Hao, Shiqi ^{[1
]}

Huang, Shu-Hong ^{[1
]}

Zhang, Zhaoqiang ^{[1
]}

机构：

[1] Shandong First Med Univ, Shandong Prov Hosp Affiliated, Sch Clin & Basic Med Sci, Jinan, Peoples R China

来源：

FRONTIERS IN MOLECULAR NEUROSCIENCE | 2022年 / 15卷

基金：

中国国家自然科学基金;

关键词：

mitophagy; neurodegenerative diseases; Alzheimer's disease; Parkinson's disease; Huntington's disease; amyotrophic lateral sclerosis; A-BETA ACCUMULATION; MUTANT HUNTINGTIN; LIFE-SPAN; MITOCHONDRIAL DYSFUNCTION; AUTOPHAGOSOME DYNAMICS; OXIDATIVE STRESS; MOUSE MODEL; PARKINSONS; PROTEIN; PATHOGENESIS;

D O I：

10.3389/fnmol.2022.1014251

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neurodegenerative diseases are a class of incurable and debilitating diseases characterized by progressive degeneration and death of cells in the central nervous system. They have multiple underlying mechanisms; however, they all share common degenerative features, such as mitochondrial dysfunction. According to recent studies, neurodegenerative diseases are associated with the accumulation of dysfunctional mitochondria. Selective autophagy of mitochondria, called mitophagy, can specifically degrade excess or dysfunctional mitochondria within cells. In this review, we highlight recent findings on the role of mitophagy in neurodegenerative disorders. Multiple studies were collected, including those related to the importance of mitochondria, the mechanism of mitophagy in protecting mitochondrial health, and canonical and non-canonical pathways in mitophagy. This review elucidated the important function of mitophagy in neurodegenerative diseases, discussed the research progress of mitophagy in neurodegenerative diseases, and summarized the role of mitophagy-related proteins in neurological diseases. In addition, we also highlight pharmacological advances in neurodegeneration.

引用

页数：11

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