Regulation of of Coronary Blood Flow in Health and Ischemic Heart Disease

被引:173
作者
Duncker, Dirk J. [1 ]
Koller, Akos [2 ,3 ]
Merkus, Daphne [1 ]
Canty, John M., Jr. [4 ]
机构
[1] Erasmus MC, Univ Med Sch, Ctr Thorax, Inst COEUR,Dept Cardiol,Div Expt Cardiol, NL-3000 CA Rotterdam, Netherlands
[2] Univ Pecs, Sch Med, Dept Pathophysiol & Gerontol, Pecs, Hungary
[3] New York Med Coll, Dept Physiol, Valhalla, NY 10595 USA
[4] SUNY Buffalo, Western New York Dept Vet Affairs Hlth Syst, Div Cardiovasc Med, Buffalo, NY USA
关键词
Coronary blood flow; Ischemic heart disease; Microvascular dysfunction; Hypertrophy; Coronary artery disease; TRANSMURAL MYOCARDIAL PERFUSION; LEFT-VENTRICULAR HYPERTROPHY; NITRIC-OXIDE; MICROVASCULAR DYSFUNCTION; ENDOTHELIAL-CELLS; ARTERY-DISEASE; CONSCIOUS DOGS; PHYSIOLOGICAL ASSESSMENT; INDUCED VASODILATION; INDUCED DILATION;
D O I
10.1016/j.pcad.2014.12.002
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The major factors determining myocardial perfusion and oxygen delivery have been elucidated over the past several decades, and this knowledge has been incorporated into the management of patients with ischemic heart disease (IHD). The basic understanding of the fluid mechanical behavior of coronary stenoses has also been translated to the cardiac catheterization laboratory where measurements of coronary pressure distal to a stenosis and coronary flow are routinely obtained. However, the role of perturbations in coronary microvascular structure and function, due to myocardial hypertrophy or coronary microvascular dysfunction, in IHD is becoming increasingly recognized. Future studies should therefore be aimed at further improving our understanding of the integrated coronary microvascular mechanisms that control coronary blood flow, and of the underlying causes and mechanisms of coronary microvascular dysfunction. This knowledge will be essential to further improve the treatment of patients with IHD. (C) 2014 Elsevier Inc. All rights reserved.
引用
收藏
页码:409 / 422
页数:14
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