Protective role of R381Q (rs11209026) polymorphism in IL-23R gene in immune-mediated diseases: A comprehensive review

被引：42

作者：

Abdollahi, Elham ^{[1
,2
,3
]}

Tavasolian, Fataneh ^{[4
]}

Momtazi-Borojeni, Amir Abbas ^{[3
,5
]}

Samadi, Morteza ^{[6
,7
]}

Rafatpanah, Houshang ^{[8
,9
]}

机构：

[1] Mashhad Univ Med Sci, Sch Med, Dept Med Immunol, Mashhad, Iran

[2] Shahid Sadoughi Univ Med Sci, Yazd, Iran

[3] Mashhad Univ Med Sci, Student Res Comm, Mashhad, Iran

[4] Tarbiat Modares Univ, Sch Med Sci, Dept Immunol, Tehran, Iran

[5] Mashhad Univ Med Sci, Dept Med Biotechnol, Mashhad, Iran

[6] Shahid Sadoughi Univ, Dept Immunol, Yazd, Iran

[7] Shahid Sadoughi Univ, Reprod Immunol Res Ctr, Yazd, Iran

[8] Iranian Acad Educ Culture & Res ACECR, Mashhad Branch, Res Ctr HIV AIDS & Viral Hepatitis HTLV1, Mashhad, Iran

[9] Mashhad Univ Med Sci, Inflammat Inflammatory Dis Res Ctr, Mashhad, Iran

来源：

JOURNAL OF IMMUNOTOXICOLOGY | 2016年 / 13卷 / 03期

关键词：

IL-23R gene; immune-mediated diseases; R381Q (rs11209026) polymorphism; INFLAMMATORY-BOWEL-DISEASE; INTERLEUKIN-23 RECEPTOR GENE; GENOME-WIDE ASSOCIATION; ACTIVE CROHNS-DISEASE; GROWTH-FACTOR-BETA; TH17; CELLS; MONOCLONAL-ANTIBODY; VARIANT RS11209026; NO ASSOCIATION; CUTTING EDGE;

D O I：

10.3109/1547691X.2015.1115448

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

Interleukin-23 (IL-23) is a regulator of cellular immune responses involved in controlling infection and autoimmune diseases. Strong evidence has shown that IL-23 plays a role in the maintenance of immune responses by influencing the proliferation and survival of IL-17-producing T-helper (T-H)-17 cells. The critical role of the IL-23/T(H)17 axis in immune-mediated diseases has emerged from different studies. It has also been seen that polymorphisms in the IL-23 receptor (IL-23R) gene might influence IL-23 responses. Interestingly, a functional single nucleotide polymorphism (SNP) in the IL-23 receptor gene (IL-23R; rs11209026, 1142 G wild-type A reduced function, Arg381Gln, R381Q) seems to confer a measure of protection against development of inflammatory bowel disease (IBD; Crohn's disease, ulcerative colitis), ankylosing spondylitis, rheumatoid arthritis, psoriasis, thyroiditis, recurrent spontaneous abortion and asthma, suggesting that a perturbation in the IL-23 signaling pathway is likely to be relevant to the pathophysiology of these diseases. The aim of this review was to provide an evaluation of what is currently known about the protective role of R381Q variant in IL-23R gene in immune-based diseases.

引用

页码：286 / 300

页数：15

共 91 条

[91] Association of Single Nucleotide Polymorphisms of IL23R and IL17 with Ulcerative Colitis Risk in a Chinese Han Population [J].