T Lymphocytes in Acute Kidney Injury and Repair

被引：40

作者：

Fathabad, Somayeh Gharaie ^{[1
]}

Kurzhagen, Johanna T. ^{[1
]}

Sadasivam, Mohanraj ^{[2
]}

Noel, Sanjeev ^{[1
]}

Bush, Errol ^{[3
]}

Hamad, Abdel R. A. ^{[2
]}

Rabb, Hamid ^{[1
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Div Nephrol, Baltimore, MD USA

[2] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Sch Med, Dept Surg, Baltimore, MD 21205 USA

来源：

SEMINARS IN NEPHROLOGY | 2020年 / 40卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Acute kidney injury; immune system; ischemia reperfusion; repair; T cells; ACUTE-RENAL-FAILURE; ISCHEMIA-REPERFUSION; TUBULAR-NECROSIS; CELL ACTIVATION; MECHANISMS; INFLAMMATION; MORTALITY; EFFECTOR; CD4(+); IMPACT;

D O I：

10.1016/j.semnephrol.2020.01.003

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Innate and adaptive immune systems participate in the pathogenesis of acute kidney injury (AKI). Considerable data from different research teams have shown the importance of T lymphocytes in the pathophysiology of AKI and, more recently, prevention and repair. T cells can generate or resolve inflammation by secreting specific cytokines and growth factors as well as interact with other immune and stromal cells to induce kidney injury or promote tissue repair. There also are emerging data on the role of T cells in the progression of AKI to chronic kidney disease and organ cross-talk in AKI. These data set the stage for immunomodulatory therapies for AKI. This review focuses on the major populations of T lymphocytes and their roles as mediators for AKI and repair. (C) 2020 Elsevier Inc. All rights reserved.

引用

页码：114 / 125

页数：12

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