Synthesis of 1,3,5-trisubstituted pyrazole-4-carboxylates through 1,3-dipolar cycloaddition of nitrilimines with allenoates

被引：8

作者：

Wang, Yulin ^{[1
]}

Xiong, Cheng ^{[1
]}

Zhong, Jiacheng ^{[1
]}

Zhou, Qingfa ^{[1
]}

机构：

[1] China Pharmaceut Univ, Dept Organ Chem, State Key Lab Nat Med, Nanjing 210009, Peoples R China

来源：

TETRAHEDRON | 2022年 / 115卷

关键词：

1,3-dipolar cycloaddition; 1,3,5-trisubstituted pyrazole-4-carboxylates; Anticancer effects; BIOLOGICAL EVALUATION; REGIOSELECTIVE SYNTHESIS; DERIVATIVES; DESIGN; INHIBITORS; PYRAZOLES; PYRAZOLE-5-CARBOXYLATES; DIAZOACETATE; CELECOXIB; RECEPTOR;

D O I：

10.1016/j.tet.2022.132790

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A strategy for the 1,3-dipolar cycloaddition of nitrilimines to delta-allenoates has been developed to provide various 1,3,5-trisubstituted pyrazole-4-carboxylates and pyrazole-4-carboxamide derivatives, which have excellent anticancer effects. This protocol exhibits characteristics of good yield, mild reaction condition, facile operation process and post-processing steps. (C) 2022 Elsevier Ltd. All rights reserved.

引用

页数：7

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