Thermographic Abnormalities are Associated with Future Digital Ulcers and Death in Patients with Systemic Sclerosis

被引：22

作者：

Hughes, Michael ^{[1
]}

Wilkinson, Jack ^{[4
]}

Moore, Tonia ^{[3
]}

Manning, Joanne ^{[3
]}

New, Paul ^{[3
]}

Dinsdale, Graham ^{[1
]}

Murray, Andrea ^{[1
,2
]}

Herrick, Ariane L. ^{[1
,5
]}

机构：

[1] Univ Manchester, Ctr Musculoskeletal Res, Manchester Acad Hlth Sci Ctr, Manchester, Lancs, England

[2] Univ Manchester, Photon Sci Inst, Manchester, Lancs, England

[3] Salford Royal NHS Fdn Trust, Dept Rheumatol, Salford, Lancs, England

[4] Salford Royal NHS Fdn Trust, Res & Dev, Manchester, Lancs, England

[5] Cent Manchester NHS Fdn Trust, Trust Manchester Acad Hlth Sci Ctr, NIHR Manchester Musculoskeletal Biomed Res Unit, Manchester, Lancs, England

来源：

JOURNAL OF RHEUMATOLOGY | 2016年 / 43卷 / 08期

关键词：

DEATH; DIGITAL ULCERS; SCLERODERMA; SYSTEMIC SCLEROSIS; THERMOGRAPHY; SECONDARY RAYNAUDS-PHENOMENON; DISTAL-DORSAL DIFFERENCE; NAILFOLD VIDEOCAPILLAROSCOPY; RISK INDEX; MULTICENTER; PATTERN; COHORT;

D O I：

10.3899/jrheum.151412

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective. Capillaroscopic abnormalities are predictive of future digital ulcers (DU). Our aim was to investigate whether functional digital vascular disease (thermographically assessed) is also associated with future DU. Methods. A retrospective case note review of patients with systemic sclerosis (SSc) undergoing thermography and who were followed for up to about 3 years. Results. There were 138 patients (equal mixture of normal/abnormal thermography). Patients with abnormal thermography were more likely to develop DU (clinician-observed and/or patient-reported, OR 2.84, p = 0.021), including multiple episodes, and more likely to die (OR 5.42, p = 0.050). Conclusion. Abnormal thermography is associated with DU and disease severity in patients with SSc.

引用

页码：1519 / 1522

页数：4

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