A wearable freestanding electrochemical sensing system

被引：109

作者：

Zhao, Yichao ^{[1
,2
]}

Wang, Bo ^{[1
]}

Hojaiji, Hannaneh ^{[1
]}

Wang, Zhaoqing ^{[1
]}

Lin, Shuyu ^{[1
]}

Yeung, Christopher ^{[1
,2
]}

Lin, Haisong ^{[1
]}

Nguyen, Peterson ^{[1
,3
]}

Chiu, Kaili ^{[1
,3
]}

Salahi, Kamyar ^{[1
]}

Cheng, Xuanbing ^{[1
,2
]}

Tan, Jiawei ^{[1
,2
]}

Cerrillos, Betto Alcitlali ^{[1
]}

Emaminejad, Sam ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Dept Elect & Comp Engn, I2BL, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Dept Mat Sci & Engn, Los Angeles, CA 90024 USA

[3] Univ Calif Los Angeles, Coll Letters & Sci, Los Angeles, CA USA

来源：

SCIENCE ADVANCES | 2020年 / 6卷 / 12期

基金：

美国国家科学基金会;

关键词：

SENSOR; ELECTRONICS; GLUCOSE;

D O I：

10.1126/sciadv.aaz0007

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

To render high-fidelity wearable biomarker data, understanding and engineering the information delivery pathway from epidermally retrieved biofluid to a readout unit are critical. By examining the biomarker information delivery pathway and recognizing near-zero strained regions within a microfluidic device, a strain-isolated pathway to preserve biomarker data fidelity is engineered. Accordingly, a generalizable and disposable freestanding electrochemical sensing system (FESS) is devised, which simultaneously facilitates sensing and out-of-plane signal interconnection with the aid of double-sided adhesion. The FESS serves as a foundation to realize a system-level design strategy, addressing the challenges of wearable biosensing, in the presence of motion, and integration with consumer electronics. To this end, a FESS-enabled smartwatch was developed, featuring sweat sampling, electrochemical sensing, and data display/transmission, all within a self-contained wearable platform. The FESS-enabled smartwatch was used to monitor the sweat metabolite profiles of individuals in sedentary and high-intensity exercise settings.

引用

页数：12

共 48 条

[1] Fingertip forces and completion time for index finger and thumb touchscreen gestures [J].

Asakawa, Deanna S. ;

Crocker, George H. ;

Schmaltz, Adam ;

Jindrich, Devin L. .

JOURNAL OF ELECTROMYOGRAPHY AND KINESIOLOGY, 2017, 34 :6-13

[2] Battery-free, skin-interfaced microfluidic/electronic systems for simultaneous electrochemical, colorimetric, and volumetric analysis of sweat [J].

Bandodkar, Amay J. ;

Gutruf, Philipp ;

Choi, Jungil ;

Lee, KunHyuck ;

Sekine, Yurina ;

Reeder, Jonathan T. ;

Jeang, William J. ;

Aranyosi, Alexander J. ;

Lee, Stephen P. ;

Model, Jeffrey B. ;

Ghaffari, Roozbeh ;

Su, Chun-Ju ;

Leshock, John P. ;

Ray, Tyler ;

Verrillo, Anthony ;

Thomas, Kyle ;

Krishnamurthi, Vaishnavi ;

Han, Seungyong ;

Kim, Jeonghyun ;

Krishnan, Siddharth ;

Hang, Tao ;

Rogers, John A. .

SCIENCE ADVANCES, 2019, 5 (01)

[3] Tattoo-Based Noninvasive Glucose Monitoring: A Proof-of-Concept Study [J].

Bandodkar, Amay J. ;

Jia, Wenzhao ;

Yardimci, Ceren ;

Wang, Xuan ;

Ramirez, Julian ;

Wang, Joseph .

ANALYTICAL CHEMISTRY, 2015, 87 (01) :394-398

[4] Wearable sweat sensors [J].

Bariya, Mallika ;

Nyein, Hnin Yin Yin ;

Javey, Ali .

NATURE ELECTRONICS, 2018, 1 (03) :160-171

[5] Substrate Selection for Fundamental Studies of Electrocatalysts and Photoelectrodes: Inert Potential Windows in Acidic, Neutral, and Basic Electrolyte [J].

Benck, Jesse D. ;

Pinaud, Blaise A. ;

Gorlin, Yelena ;

Jaramillo, Thomas F. .

PLOS ONE, 2014, 9 (10)

[6] Nanostructured platinum grass enables superior impedance reduction for neural microelectrodes [J].

Boehler, C. ;

Stieglitz, T. ;

Asplund, M. .

BIOMATERIALS, 2015, 67 :346-353

[7] A stretchable and biodegradable strain and pressure sensor for orthopaedic application [J].

Boutry, Clementine M. ;

Kaizawa, Yukitoshi ;

Schroeder, Bob C. ;

Chortos, Alex ;

Legrand, Anais ;

Wang, Zhen ;

Chang, James ;

Fox, Paige ;

Bao, Zhenan .

NATURE ELECTRONICS, 2018, 1 (05) :314-321

[8] The relationship between exercise intensity and the sweat lactate excretion rate [J].

Buono, Michael J. ;

Lee, Nanette V. L. ;

Miller, Paul W. .

JOURNAL OF PHYSIOLOGICAL SCIENCES, 2010, 60 (02) :103-107

[9] Chemo/bio-sensor networks [J].

Byrne, Robert ;

Diamond, Dermot .

NATURE MATERIALS, 2006, 5 (06) :421-424

[10] Flexible thick-film electrochemical sensors: Impact of mechanical bending and stress on the electrochemical behavior [J].

Cai, Jiaying ;

Cizek, Karel ;

Long, Brenton ;

McAferty, Kenyon ;

Campbell, Casey G. ;

Allee, David R. ;

Vogt, Bryan D. ;

La Belle, Jeff ;

Wang, Joseph .

SENSORS AND ACTUATORS B-CHEMICAL, 2009, 137 (01) :379-385

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