Protein synthesis regulation, a pillar of strength for innate immunity?

被引：13

作者：

Arguello, Rafael J. ^{[1
,2
,3
]}

Rodrigues, Christian Rodriguez ^{[1
,2
,3
]}

Gatti, Evelina ^{[1
,2
,3
,4
,5
]}

Pierre, Philippe ^{[1
,2
,3
,4
,5
]}

机构：

[1] Aix Marseille Univ, Ctr Immunol Marseille Luminy, U2M, F-13288 Marseille, France

[2] INSERM, U1104, F-13288 Marseille, France

[3] CNRS, UMR 7280, F-13288 Marseille, France

[4] Univ Aveiro, iBiMED, Biomed Res Inst, P-3810193 Aveiro, Portugal

[5] Univ Aveiro, Aveiro Hlth Sci Program, P-3810193 Aveiro, Portugal

来源：

CURRENT OPINION IN IMMUNOLOGY | 2015年 / 32卷

关键词：

PLASMACYTOID DENDRITIC CELLS; MESSENGER-RNA DECAY; CLASS-I PATHWAY; MAMMALIAN TARGET; RIG-I; TRANSLATIONAL INHIBITION; RECEPTOR ACTIVATION; KINASE MTOR; ER STRESS; INFECTION;

D O I：

10.1016/j.coi.2014.12.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recognition of pathogen derived molecules by Pattern Recognition Receptors (PRR) induces the production of cytokines (i.e. type I interferons) that stimulate the surrounding cells to transcribe and translate hundreds of genes, in order to prevent further infection and organize the immune response. Here, we report on the rising matter that metabolism sensing and gene expression control at the level of mRNA translation, allow swift responses that mobilize host defenses and coordinate innate responses to infection.

引用

页码：28 / 35

页数：8

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