Uncharged tRNA and sensing of amino acid deficiency in mammalian piriform cortex

被引：272

作者：

Hao, SZ

Sharp, JW

Ross-Inta, CM

McDaniel, BJ

Anthony, TG

Wek, RC

Cavener, DR

McGrath, BC

Rudell, JB

Koehnle, TJ

Gietzen, DW ^{[1
]}

机构：

[1] Univ Calif Davis, Sch Vet Med, Dept Anat Physiol & Cell Biol, Davis, CA 95616 USA

[2] Indiana Univ Sch Med, Dept Biochem & Mol Biol, Evansville, IN 47712 USA

[3] Indiana Univ, Sch Med, Dept Biochem & Mol Biol, Indianapolis, IN 46202 USA

[4] Penn State Univ, Dept Biol, University Pk, PA 16802 USA

[5] Univ Pittsburgh, Dept Neurosci, Pittsburgh, PA 15260 USA

来源：

SCIENCE | 2005年 / 307卷 / 5716期

关键词：

D O I：

10.1126/science.1104882

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Recognizing a deficiency of indispensable amino acids (IAAs) for protein synthesis is vital for dietary selection in metazoans, including humans. Celts in the brain's anterior piriform cortex (APC) are sensitive to IAA deficiency, Signaling diet rejection and foraging for complementary IAA sources, but the mechanism is unknown. Here we report that the mechanism for recognizing IAA-deficient foods follows the conserved general control (GC) system, wherein uncharged transfer RNA induces phosphorylation of eukaryotic initiation factor 2 (elF2) via the GC nonderepressing 2 (GCN2) kinase. Thus, a basic mechanism of nutritional stress management functions in mammalian brain to guide food selection for survival.

引用

页码：1776 / 1778

页数：3

共 29 条

[1] Preservation of liver protein synthesis during dietary leucine deprivation occurs at the expense of skeletal muscle mass in mice deleted for eIF2 kinase GCN2 [J].