The interleukin-1 cytokine family members: Role in cancer pathogenesis and potential therapeutic applications in cancer immunotherapy

被引：38

作者：

Boersma, Bart ^{[1
,2
]}

Jiskoot, Wim ^{[3
]}

Lowe, Peter ^{[4
]}

Bourquin, Carole ^{[1
,2
,5
]}

机构：

[1] Univ Geneva, Inst Pharmaceut Sci Western Switzerland, CH-1211 Geneva, Switzerland

[2] Univ Geneva, Sch Pharmaceut Sci, CH-1211 Geneva, Switzerland

[3] Leiden Univ, Leiden Acad Ctr Drug Res LACDR, Div BioTherapeut, Einsteinweg 55, NL-2333 CC Leiden, Netherlands

[4] Ctr Immunol Pierre Fabre, Inst Rech Pierre Fabre, Dept Biomol Generat & Optimizat, St Julien En Genevois, France

[5] Univ Geneva, Fac Med, Dept Anesthesiol Pharmacol & Intens Care, CH-1211 Geneva, Switzerland

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2021年 / 62卷

关键词：

Interleukin-1; family; Cancer pathogenesis; Immunotherapy; Inflammation; Protein structure; NF-KAPPA-B; RECEPTOR ACCESSORY PROTEIN; PREDICTS POOR-PROGNOSIS; INHIBITS TUMOR-GROWTH; OVARIAN-CANCER; IL-1; FAMILY; DECREASED EXPRESSION; ACQUIRED-IMMUNITY; MULTIPLE-MYELOMA; DOSE-ESCALATION;

D O I：

10.1016/j.cytogfr.2021.09.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The interleukin-1 (IL-1) family is one of the first described cytokine families and consists of eight cytokines (IL1 beta, IL-1 alpha, IL-18, IL-33, IL-36 alpha, IL-36 beta, IL-36 gamma and IL-37) and three receptor antagonists (IL-1Ra, IL-36Ra and IL38). The family members are known to play an essential role in inflammation. The importance of inflammation in cancer has been well established in the past decades. This review sets out to give an overview of the role of each IL-1 family member in cancer pathogenesis and show their potential as potential anticancer drug candidates. First, the molecular structure is described. Next, both the pro- and anti-tumoral properties are highlighted. Additionally, a critical interpretation of current literature is given. To conclude, the IL-1 family is a toolbox with a collection of powerful tools that can be considered as potential drugs or drug targets.

引用

页码：1 / 14

页数：14

共 211 条

[1]

Akla B, 2020, NEW IMMUNOCYTOKINES

[2] IL-1 receptor accessory protein is essential for IL-33-induced activation of T lymphocytes and mast cells [J].