The FERM family proteins in cancer invasion and metastasis

被引：24

作者：

Yu, Hefen ^{[1
,2
]}

Zhang, Yuxiang ^{[1
]}

Ye, Lin ^{[2
]}

Jiang, Wen G. ^{[2
]}

机构：

[1] Capital Med Univ, Sch Basic Med, Dept Biochem & Mol Biol, Beijing, Peoples R China

[2] Cardiff Univ, Dept Surg, Metastasis & Angiogenesis Res Grp, Sch Med, Cardiff CF14 4XN, S Glam, Wales

来源：

FRONTIERS IN BIOSCIENCE-LANDMARK | 2011年 / 16卷

关键词：

FERM protein; Invasion; Metastasis; Ezrin; Radixin; Moesin; Merlin; 4.1B; Ehm2; FAK; Review; FOCAL ADHESION KINASE; NF2; TUMOR-SUPPRESSOR; HUMAN SCHWANNOMA CELLS; ERM PROTEINS; ACTIN CYTOSKELETON; NEUROFIBROMATOSIS TYPE-2; BREAST CARCINOMAS; STRUCTURAL BASIS; GROWTH-FACTOR; LUNG-CANCER;

D O I：

10.2741/3803

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Metastasis is the major cause of death in patients with cancer. Metastatic cancer cells undergo dramatic molecular and cellular changes by remodeling their cell-cell and cell-matrix adhesion and their actin cytoskeleton, molecular processes that involve the activity of various signaling networks. The FERM family proteins can link transmembrane proteins to the cytoskeleton or link kinase and/or phosphatase enzymatic activity to the plasma membrane. They thus are involved not only in cell-extracellular matrix interactions and cell-cell communication but also in apoptosis, carcinogenesis and metastasis. This review will summarize the role and mechanism of FERM protein, with particular reference to the ERM and Ehm2 proteins in cancer metastasis.

引用

页码：1536 / 1550

页数：15

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