A Muscle Biosignature Differentiating Between Limb-Girdle Muscular Dystrophy and Idiopathic Inflammatory Myopathy on Magnetic Resonance Imaging

被引:3
|
作者
Hsu, Wen-Chi [1 ,2 ]
Lin, Yu-Ching [2 ,3 ]
Chuang, Hai-Hua [2 ,4 ]
Yeh, Kun-Yun [2 ,5 ]
Chan, Wing P. [6 ,7 ]
Ro, Long-Sun [2 ,8 ]
机构
[1] Chang Gung Mem Hosp, Dept Med Imaging & Intervent, Taoyuan, Taiwan
[2] Chang Gung Univ, Coll Med, Taoyuan, Taiwan
[3] Chang Gung Mem Hosp, Dept Med Imaging & Intervent, Keelung, Taiwan
[4] Chang Gung Mem Hosp, Dept Family Med, Taoyuan, Taiwan
[5] Chang Gung Mem Hosp, Dept Internal Med, Div Hemato Oncol, Keelung, Taiwan
[6] Taipei Med Univ, Wan Fang Hosp, Dept Radiol, Taipei, Taiwan
[7] Taipei Med Univ, Coll Med, Sch Med, Dept Radiol, Taipei, Taiwan
[8] Chang Gung Mem Hosp, Dept Neurol, Taoyuan, Taiwan
来源
FRONTIERS IN NEUROLOGY | 2021年 / 12卷
关键词
MRI; muscle atrophy; muscle edema; limb-girdle muscular dystrophy; inflammatory myopathy; fat substitution; MRI FINDINGS; POLYMYOSITIS; DIAGNOSIS;
D O I
10.3389/fneur.2021.783095
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: The overlapping clinical presentations of limb-girdle muscular dystrophy (LGMD) and idiopathic inflammatory myopathy (IIM) make clinical diagnosis challenging. This study provides a comprehensive evaluation of the distributions and characteristics of muscle fat substitution and edema and aims to differentiate those two diseases.Methods: This retrospective study reviewed magnetic resonance imaging (MRI) of seventeen patients with pathologically proved diagnosis, comprising 11 with LGMD and 6 with IIM. The fat-only and water-only images from a Dixon sequence were used to evaluate muscle fat substitution and edema, respectively. The degrees of muscle fat substitution and edema were graded and compared using the appropriate statistical methods.Results: In LGMD, more than 50% of patients had high-grade fat substitution in the majority of muscle groups in the thigh and calf. However, <50% of IIM patients had high-grade fat substitution in all muscle groups. Moreover, LGMD patients had significantly higher grade fat substitution than IIM patients in all large muscle groups (p < 0.05). However, there was no significant difference in edema in the majority of muscle groups, except the adductor magnus (p = 0.012) and soleus (p = 0.009) with higher grade edema in IIM. Additionally, all the adductor magnus muscles in LGMD (100%) showed high-grade fat substitution, but none of them showed high-grade edema.Conclusions: MRI could be a valuable tool to differentiate LGMD from IIM based on the discrepancy in muscle fat substitution, and the adductor magnus muscle could provide a biosignature to categorizing LGMD.
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页数:8
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