Ubiquitin-mediated proteasomal degradation in normal and malignant hematopoiesis

被引：18
作者：
Heuze, Melina L. [1 ]
Lamsoul, Isabelle [1 ]
Moog-Lutz, Christel [1 ,2 ]
Lutz, Pierre G. [1 ]
机构：
[1] Univ Toulouse 3, CNRS, UMR 5089, Inst Pharmacol & Biol Sturct, F-31077 Toulouse, France
[2] Univ Paris 06, Paris, France
来源：
BLOOD CELLS MOLECULES AND DISEASES | 2008年 / 40卷 / 02期
关键词：
ubiquitin; proteasome; E3; ligase; hematopoiesis; leukemogenesis;
D O I：
10.1016/j.bcmd.2007.07.011
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Understanding the molecular mechanisms controlling normal hematopoietic differentiation is critical to develop new treatments for blood diseases and to manipulate stem cells. Despite the identification of many players in hematopoiesis, the molecular mechanisms controlling hematopoietic differentiation remain poorly understood. Due to a number of recent findings, the targeting of regulators of hematopoiesis to proteasomal degradation might be an important step in control of this developmental program. (c) 2007 Elsevier Inc. All rights reserved.
引用
收藏
页码：200 / 210
页数：11
相关论文
共 185 条
[1]   T beta RI phosphorylation of Smad2 on Ser(465) and Ser(467) is required for Smad2-Smad4 complex formation and signaling [J].
Abdollah, S ;
MaciasSilva, M ;
Tsukazaki, T ;
Hayashi, H ;
Attisano, L ;
Wrana, JL .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (44) :27678-27685
[2]   GRAIL:: An E3 ubiquitin ligase that inhibits cytokine gene transcription is expressed in anergic CD4+ T cells [J].
Anandasabapathy, N ;
Ford, GS ;
Bloom, D ;
Holness, C ;
Paragas, V ;
Seroogy, C ;
Skrenta, H ;
Hollenhorst, M ;
Fathman, CG ;
Soares, L .
IMMUNITY, 2003, 18 (04) :535-547
[3]   Signal transduction by the TGF-β superfamily [J].
Attisano, L ;
Wrana, JL .
SCIENCE, 2002, 296 (5573) :1646-1647
[4]   Smads as transcriptional co-modulators [J].
Attisano, L ;
Wrana, JL .
CURRENT OPINION IN CELL BIOLOGY, 2000, 12 (02) :235-243
[5]   c-Myc hot spot mutations in lymphomas result in inefficient ubiquitination and decreased proteasome-mediated turnover [J].
Bahram, F ;
von der Lehr, N ;
Cetinkaya, C ;
Larsson, LG .
BLOOD, 2000, 95 (06) :2104-2110
[6]  
Ballinger CA, 1999, MOL CELL BIOL, V19, P4535
[7]  
Batard P, 2000, J CELL SCI, V113, P383
[8]   SERUM-FREE MEDIUM ALLOWS THE OPTIMAL-GROWTH OF HUMAN MEGAKARYOCYTE PROGENITORS COMPARED WITH HUMAN PLASMA SUPPLEMENTED CULTURES - ROLE OF TGF-BETA [J].
BERTHIER, R ;
VALIRON, O ;
SCHWEITZER, A ;
MARGUERIE, G .
STEM CELLS, 1993, 11 (02) :120-129
[9]   POINT MUTATIONS IN THE C-MYC TRANSACTIVATION DOMAIN ARE COMMON IN BURKITTS-LYMPHOMA AND MOUSE PLASMACYTOMAS [J].
BHATIA, K ;
HUPPI, K ;
SPANGLER, G ;
SIWARSKI, D ;
IYER, R ;
MAGRATH, I .
NATURE GENETICS, 1993, 5 (01) :56-61
[10]   Bone morphogenetic proteins regulate the developmental program of human hematopoietic stem cells [J].
Bhatia, M ;
Bonnet, D ;
Wu, DM ;
Murdoch, B ;
Wrana, J ;
Gallacher, L ;
Dick, JE .
JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (07) :1139-1147
12345678910