Signaling Networks Determining Life Span

被引：113
作者：
Riera, Celine E. [1 ,2 ,3 ]
Merkwirth, Carsten [1 ,2 ,3 ]
Daniel De Magalhaes Filho, C. [2 ,4 ]
Dillin, Andrew [1 ,2 ,3 ]
机构：
[1] Univ Calif Berkeley, Dept Mol & Cell Biol, 229 Stanley Hall, Berkeley, CA 94720 USA
[2] Howard Hughes Med Inst, Chevy Chase, MD 20815 USA
[3] Univ Calif Berkeley, Glenn Ctr Res Aging, Berkeley, CA 94720 USA
[4] Salk Inst Biol Studies, 10010 N Torrey Pines Rd, La Jolla, CA 92037 USA
来源：
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 85 | 2016年 / 85卷
关键词：
mammalian aging; nutrient sensing; insulin-like signaling; mitochondrial health; proteostasis; oxidative stress; inflammation; telomere shortening; DNA damage; epigenetic regulation; MITOCHONDRIAL-DNA MUTATIONS; C-ELEGANS LONGEVITY; NF-KAPPA-B; CAENORHABDITIS-ELEGANS; DIETARY RESTRICTION; OXIDATIVE DAMAGE; TELOMERE LENGTH; CALORIE RESTRICTION; DROSOPHILA-MELANOGASTER; METABOLIC CHECKPOINT;
D O I：
10.1146/annurev-biochem-060815-014451
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The health of an organism is orchestrated by a multitude of molecular and biochemical networks responsible for ensuring homeostasis within cells and tissues. However, upon aging, a progressive failure in the maintenance of this homeostatic balance occurs in response to a variety of endogenous and environmental stresses, allowing the accumulation of damage, the physiological decline of individual tissues, and susceptibility to diseases. What are the molecular and cellular signaling events that control the aging process and how can this knowledge help design therapeutic strategies to combat age-associated diseases? Here we provide a comprehensive overview of the evolutionarily conserved biological processes that alter the rate of aging and discuss their link to disease prevention and the extension of healthy life span.
引用
收藏
页码：35 / 64
页数：30
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