Prognostic significance of interferon regulating factor 4 in esophageal squamous cell carcinoma

被引：5
作者：
Sun, Ran [1 ]
Ye, Lin [2 ]
Zhang, Min [2 ]
Qiu, Zhu [1 ]
Xiang, Tingxiu [1 ]
Tang, Jun [1 ]
Wang, Xiangyu [3 ,4 ]
Li, Lili [3 ,4 ]
Luo, Jie [3 ,4 ]
Zhang, Dongsheng [5 ]
Ren, Guosheng [1 ]
机构：
[1] Chongqing Med Univ, Chongqing Key Lab Mol Oncol & Epigenet, Affiliated Hosp 1, Chongqing, Peoples R China
[2] Chongqing Med Univ, Affiliated Hosp 1, Dept Cardiothorac Surg, Chongqing, Peoples R China
[3] Chinese Univ Hong Kong, Sir YK Pao Ctr Canc, Canc Epigenet Lab, Dept Clin Oncol,State Key Lab Translat Oncol, Hong Kong, Hong Kong, Peoples R China
[4] Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, Hong Kong, Hong Kong, Peoples R China
[5] Sun Yat Sen Univ, Dept Med Oncol, Canc Ctr, Guangzhou 510060, Guangdong, Peoples R China
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2018年 / 506卷 / 03期
基金：
中国国家自然科学基金;
关键词：
IRF4; Cancer; Esophageal squamous cell carcinoma; Tumor-infiltrating lymphocytes (TILs); Survival; Prognosis; Biomarker; TUMOR-INFILTRATING LYMPHOCYTES; T-CELLS; CANCER; METHYLATION; SUPPRESSOR; EXPRESSION; GENE; MULTIPLE; CD4(+); IRF4;
D O I：
10.1016/j.bbrc.2018.10.142
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Background: Aberrant expression of interferon regulatory factor 4 (IRF4) has been reported in several hematologic malignancies. However, the prognostic significance of IRF4 expression in esophageal squamous cell carcinoma (ESCC) remains unknown. Methods: IRF4 protein expression in ESCC tumor specimens was determined immunohistochemically. The correlation of IRF4 expression with clinico-pathological features was assessed from a cohort of 100 patients with primary ESCC. Kaplan-Meier and Cox proportional regression analyses were used to evaluate the association between IRF4 expression and patient survival. Results: A Kaplan-Meier analysis indicated that patients with high IRF4 expression had a significantly longer overall survival rate than those with low IRF4 expression (p = 0.0006). Furthermore, multi-variate analyses revealed that IRF4 protein expression is an independent prognostic indicator for ESCC patients. Conclusion: Our results suggest that increased IRF4 protein expression correlates with improved outcome in ESCC. IRF4 may therefore represent a promising prognostic biomarker and potential immuno-therapeutic target for patients with ESCC. (C) 2018 Published by Elsevier Inc.
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收藏
页码：685 / 691
页数：7
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