Platinum(II) and palladium(II) complexes with 2-acetylpyridine thiosemicarbazone: cytogenetic and antineoplastic effects

被引：147
|
作者：
Iakovidou, Z
Papageorgiou, A
Demertzis, MA
Mioglou, E
Mourelatos, D [1 ]
Kotsis, A
Yadav, PN
Kovala-Demertzi, D
机构：
[1] Aristotelian Univ Salonika, Fac Med, Lab Med Biol & Genet, GR-54006 Salonika, Greece
[2] Univ Ioannina, Dept Chem, GR-45110 Ioannina, Greece
[3] Theagen Anticanc Inst, Lab Expt Chemotherapy, Salonika, Greece
来源：
ANTI-CANCER DRUGS | 2001年 / 12卷 / 01期
关键词：
2-acetylpyridine thiosemicarbazone; antileukemic activity; cell kinetics; palladium(II); platinum(II); sister chromatid exchanges;
D O I：
10.1097/00001813-200101000-00009
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The effect of three novel complexes of Pt(II) and three complexes of Pd(II) with 2-acetylpyridine thiosemicarbazone (HAcTsc) on sister chromatid exchange (SCE) rates and human lymphocyte proliferation kinetics on a molar basis was studied. Also, the effect of Pt(II) and Pd(II) complexes against leukemia P388 was investigated. Among these compounds, the most effective in inducing antitumor and cytogenetic effects were the complexes [Pt(AcTsc)(2)].H2O and [Pd(AcTsc)(2)] while the rest, i.e. (HAcTsc), [Pt(AcTsc)CI], [Pt(HAcTsc)(2)]Cl-2. 2H(2)O, [Pd(AcTsc)Cl] and [Pd(HAcTsc)(2)]Cl-2, displayed marginal cytogenetic and antitumor effects. [(C) 2001 Lippincott Williams & Wilkins.].
引用
收藏
页码：65 / 70
页数：6
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