Structural and functional analysis of the 5′-transcription control region for the human α2-HS glycoprotein gene

被引：9
作者：
Banine, F
Gangneux, C
Lebreton, JP
Frebourg, T
Salier, JP
机构：
[1] Fac Med Pharm, INSERM U78, F-76000 Rouen, France
[2] Inst Federat Rech Multidisciplinaires Peptides, F-76000 Rouen, France
[3] CHU Rouen, Genet Mol Lab, Rouen, France
[4] CHU Rouen, Inst Federat Rech Multidisciplinaires Peptides, Rouen, France
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 1998年 / 1398卷 / 01期
关键词：
hepatocyte; liver; liver-enriched nuclear factor; plasma protein; transcription;
D O I：
10.1016/S0167-4781(98)00042-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The human alpha2-HS glycoprotein (A2HS) and rat phosphoprotein of Mr 63000 (pp63) are homologous plasma proteins and members of the fetuin superfamily. A2HS is involved in important functions such as inhibition of the tyrosine kinase activity of the insulin receptor, regulation of calcium metabolism and osteogenesis as well as protease inhibitory activity. We report an analysis of the 5' transcription control region (4 kb) of the A2HS gene. Its most proximal 300 nt display a very potent transcriptional activity. The latter is likely accounted for by C/EBP and NF1 binding sites that are conserved from the human A2HS gene to the rat pp63 gene. In contrast, these human and rat genes appear to largely diverge beyond their proximal promoter. (C) 1998 Elsevier Science B.V. All rights reserved.
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页码：1 / 8
页数：8
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