Arginine an Enhancer of Gold Nanoparticle Induced Blocking of S-Phase Cell Cycle in HL60

被引：5

作者：

Patra, Hirak Kumar ^{[1
]}

Dasgupta, Anjan Kr ^{[1
]}

机构：

[1] Univ Calcutta, Dept Biochem, Kolkata 700019, India

来源：

ADVANCED SCIENCE LETTERS | 2011年 / 4卷 / 11-12期

关键词：

Cell Cycle Blocker; S phase; Gold Nanoparticle; Arginine; HL60; ACUTE MYELOID-LEUKEMIA; ATOMIC-BOMB SURVIVORS; OXIDATIVE STRESS; ARSENIC TRIOXIDE; CANCER; APOPTOSIS; DIAGNOSIS; LINES; CHEMOTHERAPY; INDUCTION;

D O I：

10.1166/asl.2011.3163

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Gold nanosurface has the potential to act as an anticancer agent. In this report we show that arginine conjugated gold nanoparticles can be cytotoxic to leukemia cells through the perturbation of the cell cycle. Pro-myelotic leukemia cell HL60 that can differentiate to its terminal lineage, can be arrested at the S phase of the cell cycle by such nanoparticles. Importantly, arginine, a non-toxic metabolite, serves as a dose dependent enhancer of gold nanoparticle induced cytotoxicity.

引用

页码：3770 / 3775

页数：6

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