Bakuchiol from Psoralea corylifolia inhibits the expression of inducible nitric oxide synthase gene via the inactivation of nuclear transcription factor-κB in RAW 264.7 macrophages

被引：54
作者：
Pae, HO
Cho, H
Oh, GS
Kim, NY
Song, EK
Kim, YC
Yun, YG
Kang, CL
Kim, JD
Kim, JM
Chung, HT
机构：
[1] Wonkwang Univ, Dept Neurosurg, Iksan, Chonbug, South Korea
[2] Wonkwang Univ, Dept Pediat, Iksan, Chonbug, South Korea
[3] Wonkwang Univ, Coll Pharm, Iksan, Chonbug, South Korea
[4] Wonkwang Univ, Med Resources Res Ctr, Iksan, Chonbug, South Korea
来源：
INTERNATIONAL IMMUNOPHARMACOLOGY | 2001年 / 1卷 / 9-10期
关键词：
Bakulchiol; Psoralea corylifolia; nitric oxide; inducible nitric oxide synthase mRNA; nuclear transcription factor-kappa B; anti-inflammation;
D O I：
10.1016/S1567-5769(01)00110-2
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
A large amount of nitric oxide (NO) production following the induction of inducible NO synthase (iNOS) gene has been implicated in the pathogenesis of inflammatory diseases. A phenolic compound, bakuchiol, isolated from Psoralea corylifolia L. (Leguminosae) inhibited NO production in RAW 264.7 macrophages activated with interferon-gamma and lipopolysaccharide. The mechanistic studies showed that bakuchiol inhibited the expression of iNOS mRNA through the inactivation of nuclear transcription factor-kappaB. Thus, bakuchiol may be a useful candidate for the development of a drug to treat inflammatory diseases related to iNOS gene over-expression. (C) 2001 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：1849 / 1855
页数：7
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