Synthesis and biological evaluation of pyridin-2-one nucleosides

被引：3
|
作者：
Huntley, CM
Cotterill, AS
Maillard, JY
Balzarini, J
Simons, C
机构：
[1] Univ Wales Coll Cardiff, Welsh Sch Pharm, Div Med Chem, Cardiff CF10 3XF, S Glam, Wales
[2] Univ Wales Coll Cardiff, Welsh Sch Pharm, Div Microbiol, Cardiff CF10 3XF, S Glam, Wales
[3] Katholieke Univ Leuven, Rega Inst, B-3000 Louvain, Belgium
来源：
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2001年 / 20卷 / 4-7期
关键词：
D O I：
10.1081/NCN-100002361
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The synthesis of 1-(beta -D-ribofuranosyl)pyridin-2-one-3-carboxylic acid and the 3-carboxamide as well as a short series of 3N-carboxamides, prepared by TPTU/HOBt coupling of primary amines with 1-(beta -D-ribofuranosyl)pyridin-2-one-3-carboxylic acid, and their evaluation as anti-infective agents is described.
引用
收藏
页码：731 / 733
页数：3
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