The application of metagenomic next-generation sequencing in diagnosing Chlamydia psittaci pneumonia: a report of five cases

被引：104

作者：

Gu, Lei ^{[1
,2
]}

Liu, Wei ^{[2
]}

Ru, Meng ^{[3
]}

Lin, Jing ^{[1
]}

Yu, Guoqing ^{[4
]}

Ye, Jia ^{[2
]}

Zhu, Zheng-an ^{[2
]}

Liu, Yuebin ^{[2
]}

Chen, Jian ^{[2
]}

Lai, Guoxiang ^{[2
]}

Wen, Wen ^{[2
]}

机构：

[1] Fujian Med Univ, Grad Coll, Fuzhou 350108, Peoples R China

[2] Fujian Med Univ, Xiamen Univ, Hosp Joint Logist Support Force 900, PLA,Fuzhou Gen Hosp,Dongfang Hosp,Dept Resp & Cri, Fuzhou 350025, Peoples R China

[3] PLA, Pharm Dept, Hosp Joint Logist Support Force 985, Taiyuan 030001, Peoples R China

[4] Fujian Med Univ, Xiamen Univ, Hosp Joint Logist Support Force 900, Dept Nephrol,Fuzhou Gen Hosp,PLA,Dongfang Hosp, Fuzhou 350025, Peoples R China

来源：

BMC PULMONARY MEDICINE | 2020年 / 20卷 / 01期

关键词：

mNGS; Chlamydia psittaci; Case report; COMMUNITY-ACQUIRED PNEUMONIA;

D O I：

10.1186/s12890-020-1098-x

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Background Chlamydia psittaci pneumonia is a zoonotic infectious disease caused by Chlamydia psittaci. Diagnostic tools, including culture, serologic test and PCR-based methods, are available but prone to false negative results. Case presentation This report included five cases of Chlamydia psittaci pneumonia. Symptoms and signs common to all 5 cases included fever, coughing, generalized muscle ache, and most notably, inflammatory infiltration of the lungs upon chest CT and X-ray. Metagenomic next-generation sequencing (mNGS) revealed the presence of Chlamydia psittaci in biopsy lung tissue in 3 cases and bronchoalveolar lavage fluid in the remaining 2 cases. Three patients responded to doxycycline plus moxifloxacin; two patients responded to moxifloxacin alone. Conclusions mNGS could be used to diagnose Chlamydia psittaci pneumonia.

引用

页数：7

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