Dynamic analysis of 10 components of the Chinese herbal compound Wuzhuyu-tang absorbed into rat plasma

被引：2

作者：

Gong, Muxin ^{[2
]}

Wang, Yaxun ^{[2
]}

Sun, Jian ^{[3
]}

Zhang, Qiwei ^{[1
]}

Wang, Zhimin ^{[1
]}

机构：

[1] China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100700, Peoples R China

[2] Capital Med Univ, Sch Tradit Chinese Med, Beijing 100069, Peoples R China

[3] China Acad Chinese Med Sci, Expt Res Ctr, Beijing 100700, Peoples R China

来源：

NEURAL REGENERATION RESEARCH | 2011年 / 6卷 / 33期

关键词：

Wuzhuyu-tang; absorption; migraines; portal vein; pharmacokinetics; traditional Chinese medicine; MIGRAINE; RB-1;

D O I：

10.3969/j.issn.1673-5374.2011.33.006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

To clarify the active components of Wuzhuyu-tang, this study analyzed dynamic changes of 10 ingredients of Wuzhuyu-tang in plasma using combination high performance liquid chromatography-mass spectrometry after oral administration in rats. The results showed that seven ingredients were detected in portal vein plasma after oral administration of 16.3 or 8.15 g/kg equivalent of raw material of Wuzhuyu-tang extract. The absorption rate of limonin, evodiamine, gingerol (6-Gi), and ginsenoside-Rg1 was greater than that of isorhamnetin-3-O-beta-D-glucosyl (6 '' -> 1''')-alpha-L-rhamnoside, ginsenoside-Rb1 (Rb1), and ginsenoside-Re (Re). The time most elements were absorbed into the blood was 30 to 60 minutes after administration. Re, 6-Gi and Rb1 were metabolized faster. The results suggest that the seven ingredients described above are the active components for treating migraines.

引用

页码：2594 / 2599

页数：6

共 27 条

[1] Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe): A review of recent research [J].

Ali, Badreldin H. ;

Blunden, Gerald ;

Tanira, Musbah O. ;

Nemmar, Abderrahim .

FOOD AND CHEMICAL TOXICOLOGY, 2008, 46 (02) :409-420

[2]

[Anonymous], 2005, ADM DIV PEOPL REP CH

[3]

[Anonymous], GUID SUGG CAR US LAB

[4] Effect of quercetin and its metabolites isorhamnetin and quercetin-3-glucuronide on inflammatory gene expression: role of miR-155 [J].

Boesch-Saadatmandi, Christine ;

Loboda, Agnieszka ;

Wagner, Anika E. ;

Stachurska, Anna ;

Jozkowicz, Alicja ;

Dulak, Jozef ;

Doering, Frank ;

Wolffram, Siegfried ;

Rimbach, Gerald .

JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2011, 22 (03) :293-299

[5]

CAO HX, 2004, ZHONGGUO ZHONGYAO ZA, V29, P281

[6] Migraine and ischemic stroke: a debated question [J].

Del Zotto, Elisabetta ;

Pezzini, Alessandro ;

Giossi, Alessia ;

Volonghi, Irene ;

Padovani, Alessandro .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2008, 28 (08) :1399-1421

[7]

DU LJ, 1999, ZHONGYAO YAOLI YU LI, V15, P3

[8]

GONG MX, 2009, ZHONGYAO XINYAO YU L, V20, P183

[9]

GONG MX, 2009, ZHONGGUO SHIYAN FANG, V15, P84

[10] Goshuyuto, a traditional Japanese medicine for migraine, inhibits platelet aggregation in guinea-pig whole blood [J].

Hibino, Tomoko ;

Yuzurihara, Mitsutoshi ;

Terawaki, Kiyoshi ;

Kanno, Hitomi ;

Kase, Yoshio ;

Takeda, Atsushi .

JOURNAL OF PHARMACOLOGICAL SCIENCES, 2008, 108 (01) :89-94

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