First Face Composite-Tissue Transplant Recipient Successfully Treated for Cytomegalovirus Infection with Preemptive Valganciclovir Treatment

被引：21

作者：

BenMarzouk-Hidalgo, O. J. ^{[1
]}

Cordero, E. ^{[1
]}

Gomez-Cia, T. ^{[2
]}

Sanchez, M. ^{[1
]}

Gonzalez-Padilla, J. D. ^{[3
]}

Infante-Cossio, P. ^{[3
]}

Sicilia-Castro, D. ^{[2
]}

Hernandez-Guisado, J. M. ^{[3
]}

Perez-Romero, P. ^{[1
]}

机构：

[1] Univ Seville, CSIC, Unit Infect Dis Microbiol & Prevent Med, Inst Biomed Sevilla IBiS,Univ Hosp Virgen del Roc, Seville 41013, Spain

[2] Univ Hosp Virgen del Rocio, Dept Plast & Reconstruct Surg, Seville, Spain

[3] Univ Hosp Virgen del Rocio, Unit Maxillofacial Surg, Seville, Spain

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2011年 / 55卷 / 12期

关键词：

HUMAN FACIAL ALLOTRANSPLANTATION; PROPHYLAXIS; ALLOGRAFT; DISEASE;

D O I：

10.1128/AAC.05335-11

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Little is known about cytomegalovirus (CMV) infection after face transplantation, since only two of the 11 cases of face transplantation reported worldwide have documented a CMV infection after transplantation. Herein, we present the first report of a composite-tissue face allotransplant recipient at high risk for CMV infection (D+/R- [CMV serpositive donor positive/CMV seronegative receptor]) undergoing preemptive treatment. Preemptive treatment was safe and effective for controlling CMV infection and thus promoting early acquisition of a CMV-specific immune response that protected the patient from late-onset CMV disease.

引用

收藏

页码：5949 / 5951

页数：3

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