Thymic Low Affinity/Avidity Interaction Selects Natural Th1 Cells

被引：5

作者：

Kang, Byung Hyun ^{[1
]}

Park, Hyo Jin ^{[2
]}

Yum, Hye In ^{[1
,3
]}

Park, Seung Pyo ^{[4
]}

Park, Jin Kyun ^{[5
,6
]}

Kang, Eun Ha ^{[5
,7
]}

Lee, Jae-Il ^{[1
,4
]}

Lee, Eun Bong ^{[5
,6
]}

Park, Chung-Gyu ^{[4
,8
,9
]}

Jung, Kyeong Cheon ^{[1
,2
,4
,10
]}

Park, Seong Hoe ^{[1
,4
]}

机构：

[1] Seoul Natl Univ, Coll Med, Grad Sch Immunol, Seoul 110799, South Korea

[2] Seoul Natl Univ, Coll Med, Dept Pathol, Seoul 110799, South Korea

[3] Seoul Natl Univ, Bundang Hosp, Dept Pathol, Seoul 151, South Korea

[4] Seoul Natl Univ, Coll Med, Med Res Ctr, Transplantat Res Inst, Seoul 110799, South Korea

[5] Seoul Natl Univ, Coll Med, Dept Internal Med, Seoul 110799, South Korea

[6] Seoul Natl Univ Hosp, Dept Internal Med, Div Rheumatol, Seoul 110744, South Korea

[7] Seoul Natl Univ, Bundang Hosp, Dept Internal Med, Div Rheumatol, Seoul 151, South Korea

[8] Seoul Natl Univ, Coll Med, Dept Microbiol & Immunol, Seoul 110799, South Korea

[9] Seoul Natl Univ, Coll Med, Res Ctr, Translat Xenotransplantat, Seoul 110799, South Korea

[10] Seoul Natl Univ Hosp, Dept Pathol, Seoul 110744, South Korea

来源：

JOURNAL OF IMMUNOLOGY | 2015年 / 194卷 / 12期

基金：

新加坡国家研究基金会;

关键词：

THYMOCYTE-THYMOCYTE INTERACTION; CD8(+) T-CELLS; POSITIVE SELECTION; INNATE-LIKE; EXPRESSION; MICE; DIFFERENTIATION; SIGNALS; MOUSE; REPERTOIRE;

D O I：

10.4049/jimmunol.1401628

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Identification of intrathymic eomesodermin(+) (Eomes(+)) CD4 T cells creates a novel idea that there is more than one way for the generation of innate CD4 T cells. Promyelocytic leukemia zinc finger protein(+) T cells and natural Th17 cells are known to be generated by sensing a high and persistent TCR strength, whereas this is not the case for Eomes(+) CD4 T cells. These cells go through low-level signal during the entire maturation pathway, which subsequently leads to induction of high susceptibility to cytokine IL-4. This event seems to be a major determinant for the generation of this type of cell. These T cells are functionally equivalent to Th1 cells that are present in the periphery, and this event takes place both in transgenic and in wild-type mice. There is additional evidence that this type of Eomes(+) innate CD4 T cell is also present in human cord blood.

引用

页码：5861 / 5871

页数：11

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