An Efficient Route to Difluoromethylated Pyridines

被引：43

作者：

Fujikawa, Kenichi ^{[1
]}

Kobayashi, Akira ^{[1
]}

Amii, Hideki ^{[1
]}

机构：

[1] Gunma Univ, Grad Sch Engn, Dept Chem & Chem Biol, Kiryu, Gunma 3768515, Japan

来源：

SYNTHESIS-STUTTGART | 2012年 / 44卷 / 19期

关键词：

fluorine; pyridines; copper; catalysis; cross-coupling; decarboxylations; COPPER; DITHIOPYR; ARYL; TRIFLUOROMETHYLATION; DEFLUORINATION;

D O I：

10.1055/s-0032-1316761

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient route to difluoromethylated pyridines was developed that involves copper-promoted cross-coupling of halopyridines with ethyl difluoro(trimethylsilyl)acetate and subsequent decarboxylation.

引用

页码：3015 / 3018

页数：4

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