Discovery of Natural Phenols as G Protein-Coupled Receptor-35 (GPR35) Agonists

被引：26
|
作者：
Deng, Huayun [1 ]
Hu, Haibei [1 ]
Ling, Shizhang [1 ]
Ferrie, Ann M. [1 ]
Fang, Ye [1 ]
机构：
[1] Corning Inc, Biochem Technol Sci & Technol Div, Corning, NY 14831 USA
来源：
ACS MEDICINAL CHEMISTRY LETTERS | 2012年 / 3卷 / 02期
关键词：
GPR35; natural phenols; ellagic acid; biased agonism; ACID; PRODUCTS; DRUGS; IDENTIFICATION; CELLS;
D O I：
10.1021/ml2003058
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
We report the discovery and characterization of natural phenols as G protein-coupled receptor-35 (GPR35) agonists. Pharmacological characterization using label-free dynamic mass redistribution and Tango beta-arrestin translocation assays revealed that GPR35-active natural phenols are divergent in their biased agonism.
引用
收藏
页码：165 / 169
页数：5
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