Discovery of Natural Phenols as G Protein-Coupled Receptor-35 (GPR35) Agonists

被引：26

作者：

Deng, Huayun ^{[1
]}

Hu, Haibei ^{[1
]}

Ling, Shizhang ^{[1
]}

Ferrie, Ann M. ^{[1
]}

Fang, Ye ^{[1
]}

机构：

[1] Corning Inc, Biochem Technol Sci & Technol Div, Corning, NY 14831 USA

来源：

ACS MEDICINAL CHEMISTRY LETTERS | 2012年 / 3卷 / 02期

关键词：

GPR35; natural phenols; ellagic acid; biased agonism; ACID; PRODUCTS; DRUGS; IDENTIFICATION; CELLS;

D O I：

10.1021/ml2003058

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We report the discovery and characterization of natural phenols as G protein-coupled receptor-35 (GPR35) agonists. Pharmacological characterization using label-free dynamic mass redistribution and Tango beta-arrestin translocation assays revealed that GPR35-active natural phenols are divergent in their biased agonism.

引用

页码：165 / 169

页数：5

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