Molecular Imaging of Atherosclerosis for Improving Diagnostic and Therapeutic Development

被引：102
作者：
Quillard, Thibaut [1 ]
Libby, Peter [1 ]
机构：
[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Cardiovasc Med,Dept Med, Boston, MA 02115 USA
来源：
CIRCULATION RESEARCH | 2012年 / 111卷 / 02期
基金：
美国国家卫生研究院;
关键词：
imaging; atherosclerosis; therapeutics development; CELL-ADHESION MOLECULE-1; TARGETED FUMAGILLIN NANOPARTICLES; CORONARY-ARTERY CALCIFICATION; POSITRON-EMISSION-TOMOGRAPHY; EARLY-STAGE ATHEROSCLEROSIS; IN-VIVO DETECTION; VASCULAR INFLAMMATION; CONTRAST AGENT; NONINVASIVE DETECTION; ACTIVATED PLATELETS;
D O I：
10.1161/CIRCRESAHA.112.268144
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Despite recent progress, cardiovascular and allied metabolic disorders remain a worldwide health challenge. We must identify new targets for therapy, develop new agents for clinical use, and deploy them in a clinically effective and cost-effective manner. Molecular imaging of atherosclerotic lesions has become a major experimental tool in the last decade, notably by providing a direct gateway to the processes involved in atherogenesis and its complications. This review summarizes the current status of molecular imaging approaches that target the key processes implicated in plaque formation, development, and disruption and highlights how the refinement and application of such tools might aid the development and evaluation of novel therapeutics. (Circ Res. 2012;111:231-244.)
引用
收藏
页码：231 / 244
页数：14
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