IMA: an R package for high-throughput analysis of Illumina's 450K Infinium methylation data

被引：223

作者：

Wang, Dan ^{[1
]}

Yan, Li ^{[1
]}

Hu, Qiang ^{[1
]}

Sucheston, Lara E. ^{[2
]}

Higgins, Michael J. ^{[3
]}

Ambrosone, Christine B. ^{[2
]}

Johnson, Candace S. ^{[4
]}

Smiraglia, Dominic J. ^{[5
]}

Liu, Song ^{[1
]}

机构：

[1] Roswell Pk Canc Inst, Dept Biostat, Buffalo, NY 14263 USA

[2] Roswell Pk Canc Inst, Dept Canc Prevent & Control, Buffalo, NY 14263 USA

[3] Roswell Pk Canc Inst, Dept Mol & Cellular Biol, Buffalo, NY 14263 USA

[4] Roswell Pk Canc Inst, Dept Pharmacol & Therapeut, Buffalo, NY 14263 USA

[5] Roswell Pk Canc Inst, Dept Canc Genet, Buffalo, NY 14263 USA

来源：

BIOINFORMATICS | 2012年 / 28卷 / 05期

关键词：

DNA METHYLATION; ARRAY;

D O I：

10.1093/bioinformatics/bts013

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The Illumina Infinium HumanMethylation450 BeadChip is a newly designed high-density microarray for quantifying the methylation level of over 450 000 CpG sites within human genome. Illumina Methylation Analyzer (IMA) is a computational package designed to automate the pipeline for exploratory analysis and summarization of site-level and region-level methylation changes in epigenetic studies utilizing the 450K DNA methylation microarray. The pipeline loads the data from Illumina platform and provides user-customized functions commonly required to perform exploratory methylation analysis for individual sites as well as annotated regions. Availability: IMA is implemented in the R language and is freely available from http://www.rforge.net/IMA.

引用

页码：729 / 730

页数：2

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