Melatonin attenuates glucocorticoid effect induced by medroxyprogesterone acetate in rats

被引:5
作者
Andraschko, Mariana Moreira [1 ]
De Carvalho, Mara Tais [2 ]
Pires, Hugo Cardoso Martins [1 ]
De Deus, Hellen Dorneles [3 ]
Castello, Carla Marti [2 ]
De Menezes, Liliana Borges [4 ]
Martins, Danieli Brolo [5 ]
Miguel, Marina Pacheco [4 ,6 ]
机构
[1] Univ Fed Goias, Mestre Ciencia Anim, Escola Vet & Zootecnia, Goiania, Brazil
[2] Univ Fed Goias, Mestre & Posgraduanda Ciencia Anim, Nivel doutorado, Escola Vet & Zootecnia, Goiania, Brazil
[3] Univ Fed Goias, Graduacao Farm, Goiania, Brazil
[4] Univ Fed Goias, Programa Pos Graduacao Ciencia Anim Escola Vet &, Goiania, Brazil
[5] Univ Fed Goias, Programa Pos Graduacao Ciencia Anim Escola Vet &, Goiania, Brazil
[6] Univ Fed Goias, Inst Patol Trop & Saude Publ, Goiania, Brazil
关键词
Dyslipidemia; Glucocorticoid receptor; Hormonal treatment; Hyperadrenocorticism; Progestin; PITUITARY-ADRENAL AXIS; LONG-TERM USE; CUSHINGS-SYNDROME; BODY-WEIGHT; SYNTHETIC PROGESTINS; OXIDATIVE STRESS; GENE-EXPRESSION; PLASMA LEPTIN; RECEPTOR; RISK;
D O I
10.1016/j.ygcen.2021.113959
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Medroxyprogesterone acetate (MPA) acts on glucocorticoid receptors and, when it is in excess, can cause clinical disorders comparable to hyperadrenocorticism. Melatonin (MEL) is a hormone with potent antioxidant and anti-glucocorticoid activity and it can be beneficial in the excessive activation of glucocorticoid receptors. To evaluate the protective effects of MEL on the glucocorticoid effect of MPA, 34 male Wistar rats were randomized into four groups: CON (control), MEL, MPA, and MPA + MEL. The animals were treated for 28 days, by subcutaneous injection. At the high dose that we used, the MPA caused effects compatible with an excessive activation of glucocorticoid receptors, resulting on a reduction in adrenal size, less weight gain, lower final body weight and feeding efficiency, and fewer lymphocytes compared with the control group. In addition, there was an increase in abdominal fat, cholesterol, very-low-density lipoprotein (VLDL), triglycerides, erythrocytes, hemoglobin, he-matocrit, and hepatic vacuolization. We concluded that MEL was effective reducing the mean values of total cholesterol, high-density lipoprotein (HDL), urea, VLDL, triglycerides, hepatic microvacuolization and abdom-inal fat/weight in rats treated with MPA. These findings indicate that MEL attenuates the harmful effects of MPA.
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页数:9
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