Doxorubicin-loaded pH-responsive chitin nanogels for drug delivery to cancer cells

被引：90

作者：

Jayakumar, R. ^{[1
]}

Nair, Amrita

Rejinold, N. Sanoj

Maya, S.

Nair, S. V.

机构：

[1] Amrita Vishwa Vidyapeetham Univ, Amrita Inst Med Sci, Amrita Ctr Nanosci & Mol Med, Kochi 682041, India

来源：

CARBOHYDRATE POLYMERS | 2012年 / 87卷 / 03期

关键词：

Doxorubicin loaded chitin nanogels; Cellular uptake; Swelling; pH responsivity; Cancer drug delivery;

D O I：

10.1016/j.carbpol.2011.10.040

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

This work deals with preparation of doxorubicin loaded chitin nanogels and were characterized by SEM, DLS and FTIR for cancer drug delivery. The in vitro cytotoxicity studies of 130-160 nm sized doxorubicin loaded chitin nanogels were studied using MTT assay on L929, PC3, MCF-7, A549 and HEPG2 confirmed that relatively higher toxicity on cancer cells comparing to normal L929 cells. The internalization studies showed a significant uptake of doxorubicin loaded chitin nanogels in all the tested cell lines. All the above results indicated that doxorubicin loaded chitin nanogels can be used for prostate, breast, lung and liver cancer. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：2352 / 2356

页数：5

共 8 条

[1] Detection of Adriamycin-DNA adducts by accelerator mass spectrometry at clinically relevant Adriamycin concentrations [J].