A novel DTPA cross-linking of hyaluronic acid metal complexation thereof

被引：13

作者：

Buffa, Radovan ^{[1
]}

Betak, Jiri ^{[1
]}

Kettou, Sofiane ^{[1
]}

Hermannova, Martina ^{[1
]}

Pospisilova, Lucie ^{[1
]}

Velebny, Vladimir ^{[1
]}

机构：

[1] CPN Sro, R&D Dept, Dolni Dobrouc 56102, Czech Republic

来源：

CARBOHYDRATE RESEARCH | 2011年 / 346卷 / 13期

关键词：

Hyaluronic acid; Complex; DTPA; Metal; Cross-linking;

D O I：

10.1016/j.carres.2011.04.015

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Macromolecular conjugates of a natural polysaccharide, hyaluronic acid, with diethylenetriaminepentaacetic acid (DTPA)-metal complexes were synthesized and characterized by FTIR, NMR, SEC-MALLS and ICP analysis. Several parameters of the cross-linking reaction as molecular weight of starting HA, temperature, equivalent of DTPA bis-anhydride, concentration of HA, presence of transacylation catalyst DMAP and reaction time were studied. The mechanism for the reaction was suggested and relationship between the molecular weight assigned by SEC-MALLS, reaction parameters and rheological properties of the final cross-linked products were investigated. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：1909 / 1915

页数：7

共 24 条

[1]

Aizawa A., 2000, HYDROCOLLOIDS

[2] CRITICAL EVALUATION OF STABILITY CONSTANTS OF METAL COMPLEXES OF COMPLEXONES FOR BIOMEDICAL AND ENVIRONMENTAL APPLICATIONS (IUPAC Technical Report) [J].

Anderegg, Giorgio ;

Arnaud-Neu, Francoise ;

Delgado, Rita ;

Felcman, Judith ;

Popov, Konstantin .

PURE AND APPLIED CHEMISTRY, 2005, 77 (08) :1445-1495

[3] Polymeric Contrast Agents for Magnetic Resonance Imaging: Synthesis and Characterization of Gadolinium Diethylonetriaminepentaacetic Acid Conjugated to Polysaccharides [J].

Armitage, Frances E. ;

Richardson, David E. ;

Li, King C. P. .

BIOCONJUGATE CHEMISTRY, 1990, 1 (06) :365-374

[4]

Balazs EA, 1985, US Patent, Patent No. [4500676A, 4500676]

[5] Effect of microwave irradiation on the molecular and structural properties of hyaluronan [J].

Bezakova, Zuzana ;

Hermannova, Martina ;

Drimalova, Eugenie ;

Malovikova, Anna ;

Ebringerova, Anna ;

Velebny, Vladimir .

CARBOHYDRATE POLYMERS, 2008, 73 (04) :640-646

[6] Physical properties of crosslinked hyaluronic acid hydrogels [J].

Collins, Maurice N. ;

Birkinshaw, Colin .

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 2008, 19 (11) :3335-3343

[7] Paramagnetic NMR relaxation in polymeric matrixes:: Sensitivity enhancement and selective suppression of embedded species (1H and 13C PSR filter) [J].

Fernandez-Megia, Eduardo ;

Correa, Juan ;

Novoa-Carballal, Ramon ;

Riguera, Ricardo .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2007, 129 (49) :15164-15173

[8]

Illes Janos, 2002, Acta Pharm Hung, V72, P15

[9] Reduction of adhesion formation by postoperative administration of ionically cross-linked hyaluronic acid [J].

Johns, DB ;

Rodgers, KE ;

Donahue, WD ;

Kiorpes, TC ;

diZerega, GS .

FERTILITY AND STERILITY, 1997, 68 (01) :37-42

[10] CONFORMATIONAL-CHANGES OF HYALURONATES WITH PARTIAL PALMITOYLATION AND THE ADSORPTION STRUCTURES ON THE SURFACE OF OIL DROPLETS [J].

KAWAGUCHI, Y ;

MATSUKAWA, K ;

ISHIGAMI, Y .

CARBOHYDRATE POLYMERS, 1993, 20 (03) :183-187

← 1 2 3 →