Effects of breviscapine on pulmonary inflammatory response and lung injury in children undergoing open heart surgery

被引：15

作者：

Chen, Jun ^{[1
]}

Zhao, Ying-Hua ^{[1
]}

Liu, Xiu-Lan ^{[1
]}

Chen, Xiao-Ling ^{[1
]}

Li, Jun ^{[1
]}

Lian, Qing-Quan ^{[1
]}

Xia, Yun ^{[2
]}

Shangguan, Wang-Ning ^{[1
]}

机构：

[1] Wenzhou Med Coll, Dept Anaesthesiol, Affiliated Hosp 2, Wenzhou 325027, Peoples R China

[2] Ohio State Univ, Dept Anaesthesiol, Med Ctr, Columbus, OH 43210 USA

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2012年 / 14卷 / 03期

关键词：

breviscapine; children; inflammatory response; lung injury; open heart surgery; cardiopulmonary bypass; CARDIOPULMONARY BYPASS; NEUTROPHIL ELASTASE; CARDIAC-SURGERY; PROCALCITONIN; DYSFUNCTION; INHIBITOR;

D O I：

10.1080/10286020.2011.652952

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

This study examined the effects of breviscapine (1) on pulmonary inflammatory response and lung function in pediatric patients undergoing open heart surgery. Forty-five children (ASA II or III, aged 2-72 months) were randomly assigned to control group (saline, Group C), low dose 1 group (0.5 mg/kg, Group Bre0.5), and high dose 1 group (1.0 mg/kg, Group Bre1.0), 15 cases each group. Plasma concentrations of procalcitonin (PCT) and neutrophil elastase (NE) were measured and compared at different time points. Plasma concentrations of PCT and NE were increased after cardiopulmonary bypass (CPB) induction, and the concentrations were lower in 1-treated groups. The present results indicated that continuous infusion of 1 before the CPB suppressed the production of PCT and NE attenuated systemic inflammatory response, which could result in lung protective effect in children undergoing open heart surgery.

引用

页码：270 / 275

页数：6

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