Pharmacokinetics and tissue distribution of oroxin B in rats using a validated LC-MS/MS assay

被引：0

作者：

Niu, Kai ^{[1
]}

Yan, Huiyu ^{[2
]}

Guo, Chunjie ^{[3
]}

Zhang, Sixi ^{[2
]}

Zhu, Wei ^{[1
]}

Teng, Shiyong ^{[4
]}

机构：

[1] Jilin Univ, Hosp 1, Dept Otorhinolaryngol Head & Neck Surg, Changchun, Jilin, Peoples R China

[2] Jilin Univ, Hosp 1, Dept Pharm, Changchun, Jilin, Peoples R China

[3] Jilin Univ, Hosp 1, Dept Radiol, Changchun, Jilin, Peoples R China

[4] Jilin Univ, Hosp 1, Dept Anesthesiol, Changchun 130021, Jilin, Peoples R China

来源：

BIOMEDICAL CHROMATOGRAPHY | 2019年 / 33卷 / 03期

关键词：

LC-MS/MS; oroxin B; pharmacokinetic study; tissue distribution; XANTHINE-OXIDASE INHIBITORS; LIQUID-CHROMATOGRAPHY; FLAVONOIDS; CONSTITUENTS; BARK;

D O I：

10.1002/bmc.4417

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A highly sensitive LC-MS/MS method was developed to measure oroxin B in rat plasma and tissue homogenates. The analyte and IS were isolated from biological matrices by a simple protein precipitation followed by centrifugation. Detection was conducted by electrospray negative-ionization mass spectrometry in selected-reaction monitoring mode. The assay was linear in the concentration range 4.52-904 ng/mL with intra- and inter-day precision of <14.41%. It was successfully applied to the pharmacokinetics and tissue distribution studies of oroxin B after an intravenous dose of 1.0 mg/kg in rats. The results would be useful for further development of oroxin B.

引用

页数：7

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