Genetic variants identified by GWAS was associated with colorectal cancer in the Han Chinese population

被引:2
作者
Qiao, Hui-Ping [1 ,2 ]
Zhang, Chun-Yang [1 ]
Yu, Zhi-Long [3 ]
Li, Qi-Min [1 ]
Jiao, Yang [2 ]
Cao, Jian-Ping [3 ]
机构
[1] Baotou Med Coll, Affiliated Hosp 1, Dept Radiooncol, Baotou, Peoples R China
[2] Soochow Univ, Coll Med, Dept Radiol, Suzhou, Peoples R China
[3] Inner Mongolia Med Univ, Affiliated Hosp, Dept Med & Therapeut, Hohhot, Inner Mangolia, Peoples R China
基金
中国国家自然科学基金;
关键词
Case-control study; colorectal cancer; DUSP4; TRABD2B gene; GENOME-WIDE ASSOCIATION; SUSCEPTIBILITY LOCI; METAANALYSIS; PREVALENCE; RISK;
D O I
10.4103/0973-1482.150346
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Aim of Study: Colorectal cancer (CRC), now the third most common cancer across the world, is known to aggregate in families. Recently, genome-wide association studies have identified two single nucleotide polymorphisms (SNP) associated with CRC in Caucasians. Materials and Methods: To validate whether the same variations conferred risk to CRC in the Han Chinese population, we genotyped 760 individuals (380 controls and 380 cases samples) recruited from the Han Chinese origin. Results: We found rs11987193 in 8p12 (P = 0.0472 after correction, OR = 0.751) was significantly associated with CRC but rs12080929 in 1p33 (P = 0.0650 after correction, OR = 0.750) was not. Conclusion: Our findings supported that rs11987193 is a susceptibility locus for CRC, and gene DUSP4 was possible to play a role in the pathology of CRC.
引用
收藏
页码:468 / 470
页数:3
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