Prevalence and degree of expression of the carbapenemase gene (cfiA) among clinical isolates of Bacteroides fragilis in Nottingham, UK

被引：27

作者：

Edwards, R ^{[1
]}

Hawkyard, CV

Garvey, MT

Greenwood, D

机构：

[1] Univ Nottingham Hosp, Queens Med Ctr, Div Microbiol, Nottingham NG7 2UH, England

[2] Univ Nottingham Hosp, Queens Med Ctr, PHLS Lab, Nottingham NG7 2UH, England

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 1999年 / 43卷 / 02期

关键词：

D O I：

10.1093/jac/43.2.273

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The carbapenemase gene (cfiA) was detected in 12 (6.9%) out of 175 clinical isolates of Bacteroides fragilis from Nottingham, three times the frequency reported from France. Only one gene copy was present in all cases. Eleven (6.3%) of the cfiA-positive isolates were susceptible to imipenem or meropenem (MIC < 8 mg/L); strains of this type have the potential to convert to high-level resistance. One isolate (0.6%) displayed resistance to both carbapenem antibiotics and was associated with specific carbapenemase activity six times that of the sensitive isolates.

引用

页码：273 / 276

页数：4

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