Translational aspects of pharmacological research into anxiety disorders: The stress-induced hyperthermia (SIH) paradigm

被引：77

作者：

Vinkers, Christiaan H. ^{[1
,2
]}

van Bogaert, Meg J. V. ^{[1
,2
]}

Klanker, Marianne ^{[1
,2
]}

Korte, S. Mechiel ^{[1
,2
]}

Oosting, Ronald ^{[1
,2
]}

Hanania, Taleen ^{[3
]}

Hopkins, Seth C. ^{[4
]}

Olivier, Berend ^{[1
,2
,3
,5
]}

Groenink, Lucianne ^{[1
,2
]}

机构：

[1] Univ Utrecht, Dept Psychopharmacol, UIPS, NL-3584 CA Utrecht, Netherlands

[2] Univ Utrecht, Rudolf Magnus Inst Neurosci, NL-3584 CA Utrecht, Netherlands

[3] PsychoGenics Inc, Tarrytown, NY 10591 USA

[4] Sepracor Inc, Marlborough, MA 01752 USA

[5] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT USA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2008年 / 585卷 / 2-3期

关键词：

translational animal model; stress; anxiety; stress-induced hyperthermia; SIH; emotional fever; body temperature; autonomic nervous system; thermoregulation; anxiolytic; IL-1; beta; GABA(A); GABA(A) alpha subunit; 5-HT1A; 5-HT1A knockout; strain;

D O I：

10.1016/j.ejphar.2008.02.097

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

in anxiety research, the search for models with sufficient clinical predictive validity to support the translation of animal studies on anxiolytic drugs to clinical research is often challenging. This review describes the stress-induced hyperthermia (SIH) paradigm, a model that studies the activation of the autonomic nervous system in response to stress by measuring body temperature. The reproducible and robust SIH response, combined with ease of testing, make the SIH paradigm very suitable for drug screening. We will review the current knowledge on the neurobiology of the SIH response, discuss the role of GABA(A) and serotonin (5-HT) pharmacology, as well as how the SIH response relates to infectious fever. Furthermore, we will present novel data on the SIH response variance across different mice and their sensitivity to anxiolytic drugs. The SIH response is an autonomic stress response that can be successfully studied at the level of its physiology, pharmacology, neurobiology and genetics and possesses excellent animal-to-human translational properties. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：407 / 425

页数：19

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