Animal models of frailty: current applications in clinical research

被引：44
作者：
Kane, Alice E. [1 ]
Hilmer, Sarah N. [2 ,3 ,4 ,5 ]
Mach, John [2 ,3 ,4 ,5 ]
Mitchell, Sarah J. [6 ]
de Cabo, Rafael [6 ]
Howlett, Susan E. [1 ]
机构：
[1] Dalhousie Univ, Dept Pharmacol, Halifax, NS, Canada
[2] Univ Sydney, Kolling Inst Med Res, Sydney, NSW, Australia
[3] Univ Sydney, Sydney Med Sch, Sydney, NSW, Australia
[4] Royal North Shore Hosp, Dept Clin Pharmacol, Sydney, NSW, Australia
[5] Royal North Shore Hosp, Dept Aged Care, Sydney, NSW, Australia
[6] NIA, NIH, Baltimore, MD 21224 USA
来源：
CLINICAL INTERVENTIONS IN AGING | 2016年 / 11卷
基金：
美国国家卫生研究院;
关键词：
mouse models; frailty index; frailty phenotype; IL-10; knock-out; SKELETAL-MUSCLE; OLDER-ADULTS; EXERCISE INTERVENTIONS; SERUM-ALBUMIN; LIFE-SPAN; MICE; AGE; INFLAMMATION; MORTALITY; PEOPLE;
D O I：
10.2147/CIA.S105714
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
The ethical, logistical, and biological complications of working with an older population of people inherently limits clinical studies of frailty. The recent development of animal models of frailty, and tools for assessing frailty in animal models provides an invaluable opportunity for frailty research. This review summarizes currently published animal models of frailty including the interleukin-10 knock-out mouse, the mouse frailty phenotype assessment tool, and the mouse clinical frailty index. It discusses both current and potential roles of these models in research into mechanisms of frailty, interventions to prevent/delay frailty, and the effect of frailty on outcomes. Finally, this review discusses some of the challenges and opportunities of translating research findings from animals to humans.
引用
收藏
页码：1519 / 1529
页数：11
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