Spectral polarization imaging of human prostate cancer tissue using a near-infrared receptor-targeted contrast agent

被引：63

作者：

Pu, Y

Wang, WB

Tang, GC

Zeng, F

Achilefu, S

Vitenson, JH

Sawczuk, I

Peters, S

Lombardo, JM

Alfano, RR

机构：

[1] CUNY City Coll, Dept Elect Engn, New York, NY 10031 USA

[2] CUNY City Coll, Dept Phys, New York, NY 10031 USA

[3] Washington Univ, Sch Med, St Louis, MO 63110 USA

[4] Hackensack Univ, Ctr Med, Dept Urol, Hackensack, NJ 07601 USA

[5] Hackensack Univ, Ctr Med, Dept Pathol, Hackensack, NJ 07601 USA

[6] Hackensack Univ, Ctr Med, Dept Urol, Hackensack, NJ 07601 USA

[7] Columbia Univ, Coll Phys & Surg, New York, NY 10032 USA

[8] Univ Med & Dent New Jersey, Newark Med Sch, Newark, NJ 07103 USA

来源：

TECHNOLOGY IN CANCER RESEARCH & TREATMENT | 2005年 / 4卷 / 04期

关键词：

prostate cancer; receptor-targeted; peptide analogue conjugate; contrast agent; spectral polarization imaging; near-infrared; absorption; fluorescence;

D O I：

10.1177/153303460500400410

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The Cypate-Bombesin Peptide Analogue Conjugate (Cybesin) was used as a prostate tumor receptor-targeted contrast agent. The absorption and fluorescence spectra of Cybesin were measured and shown to exist in the NIR tissue "optical window". The spectral polarization imaging of Cybesin-stained prostate cancerous and normal tissues shows that prostate cancerous tissue takes-up more Cybesin than that of prostate normal tissue, making Cybesin a potential marker of prostate cancer.

引用

页码：429 / 436

页数：8

共 17 条

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