Coordination chemistry of vanadium in metallopharmaceutical candidate compounds

被引：333

作者：

Thompson, KH ^{[1
]}

Orvig, C ^{[1
]}

机构：

[1] Univ British Columbia, Dept Chem, Med INorgan Chem Grp, Vancouver, BC V6T 1Z1, Canada

来源：

COORDINATION CHEMISTRY REVIEWS | 2001年 / 219卷

基金：

英国医学研究理事会; 加拿大自然科学与工程研究理事会;

关键词：

vanadium complexes; diabetes mellitus; cancer; pharmaceutical agents; ESEEM; structure-activity relationships; bioactivity;

D O I：

10.1016/S0010-8545(01)00395-2

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The discovery of vanadium's insulin-like behaviour in vitro, and later of the orally available glucose- and lipid-lowering capability of these same compounds in vivo, has stimulated renewed interest in vanadium coordination chemistry. Besides the anti-diabetic effects for which it is now so well known, vanadium also exhibits a number of other therapeutic effects including anti-tumour and anti-inflammatory activities. In this review, emphasis will be on the most recent developments in the coordination chemistry of vanadium(III), (IV) and (V), as related to development of these compounds for pharmaceutical use. How best to measure bioactivity and the pharmaceutical relevance of accompanying increased oxidative stress will also be considered. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：1033 / 1053

页数：21

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