Macula and Retinal Nerve Fiber Layer in Migraine Patients: Analysis By Spectral Domain Optic Coherence Tomography

被引：30

作者：

Yulek, Fatma ^{[1
]}

Dirik, Ebru Bilge ^{[2
]}

Eren, Yasemin ^{[2
]}

Simavli, Huseyin ^{[3
,4
]}

Ugurlu, Nagihan ^{[1
]}

CagIl, Nurullah ^{[1
]}

Simsek, Saban ^{[5
]}

机构：

[1] Yildirim Beyazit Univ, Ankara Ataturk Educ & Training Hosp, Fac Med, Dept Ophthalmol, Ankara, Turkey

[2] Yildirim Beyazit Univ, Ankara Ataturk Educ & Training Hosp, Fac Med, Dept Neurol, Ankara, Turkey

[3] Harvard Univ, Massachusetts Eye & Ear Infirm, Sch Med, Dept Ophthalmol, Boston, MA 02114 USA

[4] Izzet Baysal Bolu State Hosp, Dept Ophthalmol, Bolu, Turkey

[5] Maltepe Univ, Fac Med, Dept Ophthalmol, Istanbul, Turkey

来源：

SEMINARS IN OPHTHALMOLOGY | 2015年 / 30卷 / 02期

关键词：

Ganglion cell complex thickness; macular thickness; migraine; nerve fiber layer thickness; spectral domain optical coherence tomography; LOW-TENSION GLAUCOMA; OPEN-ANGLE GLAUCOMA; THICKNESS MEASUREMENTS; REPRODUCIBILITY; HEADACHE; ASSOCIATION; VASOSPASM; CORTEX; SCALES; BLOOD;

D O I：

10.3109/08820538.2013.833270

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Aim: Investigating the retinal nerve fiber layer (RNFL), macular and ganglion cell complex thickness in eyes of migraine patients using optical coherence tomography. Methods: The study was designed as an observational cross-sectional study. 50 patients with migraine (30 patients with aura and 20 patients without aura) and 50 healthy volunteers were included. Optical coherence tomography was performed with Optovue technology. The fast RNFL thickness (3.4) scan, MM5, and GCC acquisition protocols were used. Results: There was no statistically significant difference in retinal thickness in any of the quadrants between the control group and the migraine patients (p>0.05). The average RNFL thickness (110.50 vs 102.84 microns, p = 0.03) was significantly thinner in migrainers as compared to the control. The ANOVA did not reveal any significant difference between migrainers with aura, migrainers without aura, and the control group. The VAS (visual analogue scale) score of migraine patients was not statistically significantly correlated with any of the parameters, while the length of migraine history was negatively correlated with the average RNFL thickness (r = -0.32, p = 0.03). Conclusion: The average RNFL thickness in the migraine patients was found to be thinner than that in the control group. In addition, we found a negative weak correlation between length of migraine history and the average RNFL thickness, supporting the possible association between these pathologies.

引用

页码：124 / 128

页数：5

共 25 条

[1] Reproducibility of peripapillary retinal nerve fiber thickness measurements with stratus OCT in glaucomatous eyes [J].

Budenz, Donald L. ;

Fredette, Marie-Josee ;

Feuer, William J. ;

Anderson, Douglas R. .

OPHTHALMOLOGY, 2008, 115 (04) :661-666

[2] Spectral domain optical coherence tomography - Ultra-high speed, ultra-high resolution ophthalmic imaging [J].

Chen, TC ;

Cense, B ;

Pierce, MC ;

Nassif, N ;

Park, BH ;

Yun, SH ;

White, BR ;

Bouma, BE ;

Tearney, GJ ;

de Boer, JF .

ARCHIVES OF OPHTHALMOLOGY, 2005, 123 (12) :1715-1720

[3] Migraine and tension headache in high-pressure and normal-pressure glaucoma [J].

Cursiefen, C ;

Wisse, M ;

Cursiefen, S ;

Jünemann, A ;

Martus, P ;

Korth, M .

AMERICAN JOURNAL OF OPHTHALMOLOGY, 2000, 129 (01) :102-104

[4] STUDIES WITH PAIN RATING-SCALES [J].

DOWNIE, WW ;

LEATHAM, PA ;

RHIND, VM ;

WRIGHT, V ;

BRANCO, JA ;

ANDERSON, JA .

ANNALS OF THE RHEUMATIC DISEASES, 1978, 37 (04) :378-381

[5] ARTERIOGRAPHIC DEMONSTRATION OF SPASM OF THE INTRACRANIAL ARTERIES - WITH SPECIAL REFERENCE TO SACCULAR ARTERIAL ANEURISMS [J].

ECKER, A ;

RIEMENSCHNER, PA .

JOURNAL OF NEUROSURGERY, 1951, 8 (06) :660-667

[6] Microscopical observations on the circulation of the blood in the cerebral cortex. [J].

Florey, H .

BRAIN, 1925, 48 :43-64

[7] OCULAR VASOSPASM - A RISK FACTOR IN THE PATHOGENESIS OF LOW-TENSION GLAUCOMA [J].

GASSER, P .

INTERNATIONAL OPHTHALMOLOGY, 1989, 13 (04) :281-290

[8] INFLUENCE OF VASOSPASM ON VISUAL FUNCTION [J].

GASSER, P ;

FLAMMER, J .

DOCUMENTA OPHTHALMOLOGICA, 1987, 66 (01) :3-18

[9]

Gull W., 1859, Guys Hosp Rep, V5, P281

[10] Mechanisms of migraine aura revealed by functional MRI in human visual cortex [J].

Hadjikhani, N ;

del Rio, MS ;

Wu, O ;

Schwartz, D ;

Bakker, D ;

Fischl, B ;

Kwong, KK ;

Cutrer, FM ;

Rosen, BR ;

Tootell, RBH ;

Sorensen, AG ;

Moskowitz, MA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (08) :4687-4692

← 1 2 3 →